The general objectives of the San Francisco Men's Health Study (SFMHS) are: (a) To better understand the natural history of HIV infection (b) To determine the risk factors and appropriate interventions to limit the spread of the disease and (c) To characterize any biologic or environmental factors that will alter the natural history of the disease (e.g., either limit or accelerate the morbidity and mortality associated with infection) in this population. The specific objectives of the SFMHS are: (1) To continue to study the natural history of HIV infection among a population of homosexual/bisexual men who have been enrolled in the SFMHS since 1983, specifically by collecting demographic, socio-cultural and self-reported behavioral data and statistically correlating these data with physical examination findings, HIV antibody status, immunologic and hematologic parameters and the presence of antibodies to other viruses. (2) To determine the rate of disease progression by comparing laboratory findings (HLA-type, CBC, SMA-12), immunologic parameters (by flow cytometry), physical examinations, and electromechanical findings (EEG, EKG, MRI, CAT, nerve conduction studies, radiographic findings) with behavioral risk factors and demographic characteristics. (3) To determine the rate of seroconversion among sexually active participants and to determine those behaviors which may alter the rate of seroconversion. (4) To determine the nature and extent of co-infections among sexually active homosexual men and their impact on the natural history of HIV infection.N01CP85604 The purpose of this project is to attain (nonprofessional), managerial, and clerical support for epidemiologic studies of cancer risk following radiation and related exposures. The contractor functions in a supportive role carrying out specific tasks and does not engage in independent research. All phases of support services are supplied including preparing data collection forms, preparing abstraction and interviewing manuals, conducting field studies, obtaining death certificates, locating populations for vital status determination, assessing exposure information, and creating and manipulating data files.

Project Start
1988-07-01
Project End
1991-09-29
Budget Start
1989-02-28
Budget End
1990-09-29
Support Year
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of California Berkeley
Department
Other Health Professions
Type
Schools of Public Health
DUNS #
094878337
City
Berkeley
State
CA
Country
United States
Zip Code
94704
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Michael, N L; Chang, G; d'Arcy, L A et al. (1995) Functional characterization of human immunodeficiency virus type 1 nef genes in patients with divergent rates of disease progression. J Virol 69:6758-69
Johnson, D; Hirschkorn, D; Busch, M P (1995) Evaluation of four alternative methodologies for determination of absolute CD4+ lymphocyte counts. The National Heart, Lung, and Blood Institute Retrovirus Epidemiology Donor Study. J Acquir Immune Defic Syndr Hum Retrovirol 10:522-30

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