Abstract

Furnish all necessary personnel, labor, patients, facilities, equipment, materials, and supplies required to conduct Phase II and Phase III studies in patients with disseminated solid tumors such as: cancers of the lung, breast, prostate, bladder, kidney, testicle, ovary, endometrium, cervix, head and neck, stomach, pancreas, and colon, as well as lymphomas, melanomas, and bone and soft tissue sarcomas. Seventy-five patients are required for the first four month period with 250 patients per year for the next four years. The final year of the contract is for patient treatment and follow-up only. Patients to be studied, accrued, and treated for each tumor type to be dictated by the particular protocols approved.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CM007337-011
Application #
3608097
Study Section
Project Start
1980-09-15
Project End
1986-01-14
Budget Start
1985-04-01
Budget End
1985-07-01
Support Year
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Memorial Hospital for Cancer & Allied Di
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10021

  Publications

Kraus, D H; Pfister, D G; Harrison, L B et al. (1995) Salvage laryngectomy for unsuccessful larynx preservation therapy. Ann Otol Rhinol Laryngol 104:936-41
Pfister, D G; Harrison, L B; Strong, E W et al. (1995) Organ-function preservation in advanced oropharynx cancer: results with induction chemotherapy and radiation. J Clin Oncol 13:671-80
Pfister, D G; Bajorin, D; Motzer, R et al. (1994) Cisplatin, fluorouracil, and leucovorin. Increased toxicity without improved response in squamous cell head and neck cancer. Arch Otolaryngol Head Neck Surg 120:89-95
Pfister, D G; Strong, E; Harrison, L et al. (1991) Larynx preservation with combined chemotherapy and radiation therapy in advanced but resectable head and neck cancer. J Clin Oncol 9:850-9
Bosl, G J; Geller, N L; Chan, E Y (1988) Stage migration and the increasing proportion of complete responders in patients with advanced germ cell tumors. Cancer Res 48:3524-7
Bosl, G J; Geller, N L; Bajorin, D (1988) Identification and management of poor risk patients with germ cell tumors: the Memorial Sloan-Kettering Cancer Center experience. Semin Oncol 15:339-44
Evans, L M; Casper, E S; Rosenbluth, R (1987) Phase II trial of carboplatin in advanced malignant melanoma. Cancer Treat Rep 71:171-2
Kelsen, D P; Buckner, J; Einzig, A et al. (1987) Phase II trial of cisplatin and etoposide in adenocarcinomas of the upper gastrointestinal tract. Cancer Treat Rep 71:329-30
Kelsen, D P; Fein, R; Coonley, C et al. (1986) Cisplatin, vindesine, and mitoguazone in the treatment of esophageal cancer. Cancer Treat Rep 70:255-9
Leitner, S P; Bosl, G J; Strong, E W et al. (1986) A pilot study of cisplatin-vinblastine as the initial treatment of advanced head and neck cancer. Cancer 58:1014-7

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