Furnish all necessary personnel, labor, patients, facilities, equipment, materials, and supplies required to conduct Phase II and Phase III studies in patients with disseminated solid tumors such as: cancers of the lung, breast, prostate, bladder, kidney, testicle, ovary, endometrium, cervix, head and neck, stomach, pancreas, and colon, as well as lymphomas, melanomas, and bone and soft tissue sarcomas. Seventy-five patients are required for the first four month period with 250 patients per year for the next four years. The final year of the contract is for patient treatment and follow-up only. Patients to be studied, accrued, and treated for each tumor type to be dictated by the particular protocols approved.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CM007405-008
Application #
3608361
Study Section
Project Start
1980-09-15
Project End
1986-02-14
Budget Start
1985-03-25
Budget End
1986-02-14
Support Year
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Natale, R B; Cody, R L; Simon, M S et al. (1993) An in vivo and in vitro trial of aclarubicin in metastatic breast cancer: a novel approach to the study of analogs. Cancer Chemother Pharmacol 31:485-8
Simon, M S; Eckenrode, J; Natale, R B (1990) Phase II trial of methylglyoxal bis-guanylhydrazone (MGBG) in refractory small cell lung cancer. Invest New Drugs 8 Suppl 1:S79-81
Dabich, L; Liepman, M K (1988) Cisplatin, VP-16-213 and MGBG (methylglyoxal bis guanylhydrazone) combination chemotherapy in refractory lymphoma, a phase II study. Invest New Drugs 6:231-7
Forastiere, A A; Perry, D J; Wolf, G T et al. (1988) Cisplatin and mitoguazone. An induction chemotherapy regimen in advanced head and neck cancer. Cancer 62:2304-8
Forastiere, A A; Natale, R B; Takasugi, B J et al. (1987) A phase I-II trial of carboplatin and 5-fluorouracil combination chemotherapy in advanced carcinoma of the head and neck. J Clin Oncol 5:190-6
Vogel, W C; Forastiere, A A; Natale, R B et al. (1987) Phase II trial of N-methylformamide in advanced head and neck cancer. Invest New Drugs 5:203-6
Forastiere, A A; Gennis, M; Orringer, M B et al. (1987) Cisplatin, vinblastine, and mitoguazone chemotherapy for epidermoid and adenocarcinoma of the esophagus. J Clin Oncol 5:1143-9
Natale, R B; Wheeler, R H; Roberts, J A (1987) Cisplatin and dichloromethotrexate: a pharmacologically rational combination. NCI Monogr :219-23
Takasugi, B J; Perry, D J; Wheeler, R H et al. (1986) A phase II trial of cisplatin and methylglyoxal bis-guanylhydrazone (MGBG) in recurrent squamous cell carcinoma of the head and neck. Am J Clin Oncol 9:299-301
Forastiere, A A; Natale, R B; Wheeler, R R (1986) Phase II trial of methylglyoxal bis (guanylhydrazone) (MGBG) in advanced head and neck cancer. Cancer 58:2585-8

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