Abstract

The efficacy of chemopreventive agents is tested against clinically-normal colon epithelial cells derived from mice predisposed to colon cancer. The primary cell cultures are expanded in culture and assayed for surrogate biomarkers prior to and following their spontaneous immortalization in the presence or absence of chemopreventive agents. The mutant mice used are as follows: MIN, MLH1, APC/MLH1, and SMAD4.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Prevention And Control (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CN005107-000
Application #
6352449
Study Section
Project Start
2000-08-01
Project End
Budget Start
2000-08-01
Budget End
2002-07-31
Support Year
Fiscal Year
2000
Total Cost
$349,968
Indirect Cost

  Institution

Name
Strang Cancer Prevention Center
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10021