Agency
National Institute of Health (NIH)
Institute
Office of The Director, NCI (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CO056000-037
Application #
2881463
Study Section
Project Start
1995-02-24
Project End
1999-09-25
Budget Start
1998-09-30
Budget End
1999-07-10
Support Year
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Science Applications International Corp
Department
Type
DUNS #
City
San Diego
State
CA
Country
United States
Zip Code
92121
Beck, Daniel E; Lv, Wei; Abdelmalak, Monica et al. (2016) Synthesis and biological evaluation of new fluorinated and chlorinated indenoisoquinoline topoisomerase I poisons. Bioorg Med Chem 24:1469-79
Beck, Daniel E; Abdelmalak, Monica; Lv, Wei et al. (2015) Discovery of potent indenoisoquinoline topoisomerase I poisons lacking the 3-nitro toxicophore. J Med Chem 58:3997-4015
Lv, Peng-Cheng; Agama, Keli; Marchand, Christophe et al. (2014) Design, synthesis, and biological evaluation of O-2-modified indenoisoquinolines as dual topoisomerase I-tyrosyl-DNA phosphodiesterase I inhibitors. J Med Chem 57:4324-36
Wieland, S F; Asabe, S; Engle, R E et al. (2014) Limited hepatitis B virus replication space in the chronically hepatitis C virus-infected liver. J Virol 88:5184-8
Beck, Daniel E; Agama, Keli; Marchand, Christophe et al. (2014) Synthesis and biological evaluation of new carbohydrate-substituted indenoisoquinoline topoisomerase I inhibitors and improved syntheses of the experimental anticancer agents indotecan (LMP400) and indimitecan (LMP776). J Med Chem 57:1495-512
Ma, Liang; Huang, Da-Wei; Cuomo, Christina A et al. (2013) Sequencing and characterization of the complete mitochondrial genomes of three Pneumocystis species provide new insights into divergence between human and rodent Pneumocystis. FASEB J 27:1962-72
Peterson, Katherine E; Cinelli, Maris A; Morrell, Andrew E et al. (2011) Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors: investigating the relationships involving stereochemistry, hydrogen bonding, and biological activity. J Med Chem 54:4937-53
Huang, Da Wei; Sherman, Brad T; Lempicki, Richard A (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4:44-57
Huang, Da Wei; Sherman, Brad T; Zheng, Xin et al. (2009) Extracting biological meaning from large gene lists with DAVID. Curr Protoc Bioinformatics Chapter 13:Unit 13.11
Liao, Shu-Yuan; Lerman, Michael I; Stanbridge, Eric J (2009) Expression of transmembrane carbonic anhydrases, CAIX and CAXII, in human development. BMC Dev Biol 9:22

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