The objective of this project is to characterize dose-response relationships and toxicity of primaclone and oxymethalone administrated by dosed feed to rats and mice in 14-day repeated-dose, 90-day subchronic, and 2-year chronic studies. Animals will be treated and libitum for 14 and 90 days or 2 years. At the end of each study, all animals will be given gross and microscopic histopathologic evaluations. Hematology, clinical chemistry, and sperm morphology/vaginal cytology will be performed in the 90-day study. The results of each study will be used by NTP to establish doses to be used in the next study (i.e., the 14-day results for the 90-day study; the 90-day results for the chronic study).

Project Start
1990-06-05
Project End
1995-11-30
Budget Start
1994-06-22
Budget End
1995-06-15
Support Year
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Battelle Memorial Institute
Department
Type
DUNS #
City
Columbus
State
OH
Country
United States
Zip Code
43201