The objective of this contract is to have a Data Coordinating Center organize a clinical trial of calcium supplementation in pregnancy for the prevention of preeclampsia and preterm birth. The Data Coordinating Center shall provide daily assistance to clinical investigators, insuring that the protocol is followed, assuring the quality of data collected, and providing feedback to the steering committee or the Project Office on study progress within a short turn around time.

Project Start
1991-03-18
Project End
1995-03-17
Budget Start
1991-03-18
Budget End
1992-03-17
Support Year
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Emmes Corporation
Department
Type
DUNS #
City
Rockville
State
MD
Country
United States
Zip Code
20850
Levine, Richard J; Vatten, Lars J; Horowitz, Gary L et al. (2009) Pre-eclampsia, soluble fms-like tyrosine kinase 1, and the risk of reduced thyroid function: nested case-control and population based study. BMJ 339:b4336
Holston, Alexander M; Qian, Cong; Yu, Kai F et al. (2009) Circulating angiogenic factors in gestational proteinuria without hypertension. Am J Obstet Gynecol 200:392.e1-10
Signore, Caroline; Mills, James L; Qian, Cong et al. (2008) Circulating soluble endoglin and placental abruption. Prenat Diagn 28:852-8
Habli, Mounira; Levine, Richard J; Qian, Cong et al. (2007) Neonatal outcomes in pregnancies with preeclampsia or gestational hypertension and in normotensive pregnancies that delivered at 35, 36, or 37 weeks of gestation. Am J Obstet Gynecol 197:406.e1-7
Levine, Richard J; Lam, Chun; Qian, Cong et al. (2006) Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 355:992-1005
Levine, Richard J; Qian, Cong; Maynard, Sharon E et al. (2006) Serum sFlt1 concentration during preeclampsia and mid trimester blood pressure in healthy nulliparous women. Am J Obstet Gynecol 194:1034-41
Beste, Lauren A; England, Lucinda J; Schisterman, Enrique F et al. (2005) Pregnancy outcomes in smokers who develop pre-eclampsia. Paediatr Perinat Epidemiol 19:12-8
Levine, Richard J; Thadhani, Ravi; Qian, Cong et al. (2005) Urinary placental growth factor and risk of preeclampsia. JAMA 293:77-85
Emery, Stephen P; Levine, Richard J; Qian, Cong et al. (2005) Twenty-four-hour urine insulin as a measure of hyperinsulinaemia/insulin resistance before onset of pre-eclampsia and gestational hypertension. BJOG 112:1479-85
Levine, Richard J; Qian, Cong; Leshane, Erik S et al. (2004) Two-stage elevation of cell-free fetal DNA in maternal sera before onset of preeclampsia. Am J Obstet Gynecol 190:707-13

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