The objective of this contract is to continue the operation and maintenance of a biological testing facility for the exclusive use of the Contraceptive Development Branch (CDB). The contractor shall undertake a broad spectrum of antifertility and biochemical tests, screening and assay for hormonal activity, radioimmunoassay and radioreceptor assay of natural and synthetic hormones as well as test substances, preclinical pharmacokinetic and safety evaluation including, where required, conduct under GLP guidelines, and maintain rodents, rabbits and rhesus monkeys.
| Hild, S A; Reel, J R; Hoffman, L H et al. (2000) CDB-2914: anti-progestational/anti-glucocorticoid profile and post-coital anti-fertility activity in rats and rabbits. Hum Reprod 15:822-9 |
| Larner, J M; Reel, J R; Blye, R P (2000) Circulating concentrations of the antiprogestins CDB-2914 and mifepristone in the female rhesus monkey following various routes of administration. Hum Reprod 15:1100-6 |
| Rivier, J; Jiang, G C; Lahrichi, S L et al. (1996) Dose relationship between GnRH antagonists and pituitary suppression. Hum Reprod 11 Suppl 3:133-47 |
