The overall objective of this program is to support a multicenter case- control study on the potential etiologic factors for sarcoidosis. The cases will also be followed to gain information on the natural history of this disease including risk factors for progression of disease. A steering committee will develop a protocol and manual of operations which will address the most promising hypotheses to be pursued to identify the cause(s) of sarcoidosis. The protocol will include a comprehensive clinical characterization of each participant and determination of markers of immune responsiveness. Participation in a system for banking biological specimens will be required of each clinical center. The clinical coordinating center will collect, manage and analyze the data collected from the clinical centers. The clinical coordinating center will coordinate writing of the protocol and manual of operations, manage the logistics of the biological banking system, be responsible for setting up the data entry procedures and managing the database, be responsible for the logistics of the steering committee and Data and Safety Monitoring Board meetings, and perform the statistical analysis of the final data set. A six year schedule is envisioned as follows: Phase I (12 Months): A collaborative protocol and manual of operations will be developed; Phase II (48 Months): will involve the recruitment and follow-up of cases, patients and recruitment and interviewing of control subjects, and Phase III (12 Months): will involve data analysis.
| McDougal, Kathryn E; Fallin, M Daniele; Moller, David R et al. (2009) Variation in the lymphotoxin-alpha/tumor necrosis factor locus modifies risk of erythema nodosum in sarcoidosis. J Invest Dermatol 129:1921-6 |
| Rossman, M D; Thompson, B; Frederick, M et al. (2008) HLA and environmental interactions in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 25:125-32 |
| Wasfi, Y S; Silveira, L J; Jonth, A et al. (2008) Fas promoter polymorphisms: genetic predisposition to sarcoidosis in African-Americans. Tissue Antigens 72:39-48 |
| Zheng, Gang; Tian, Xin; ACCESS Research Group (2006) Robust trend tests for genetic association using matched case-control design. Stat Med 25:3160-73 |
| Baughman, R P; Judson, M A; Teirstein, A et al. (2006) Presenting characteristics as predictors of duration of treatment in sarcoidosis. QJM 99:307-15 |
| Yeager, Henry; Rossman, Milton D; Baughman, Robert P et al. (2005) Pulmonary and psychosocial findings at enrollment in the ACCESS study. Sarcoidosis Vasc Diffuse Lung Dis 22:147-53 |
| Kreider, Mary Elizabeth; Christie, Jason D; Thompson, Bruce et al. (2005) Relationship of environmental exposures to the clinical phenotype of sarcoidosis. Chest 128:207-15 |
| Barnard, Juliana; Rose, Cecile; Newman, Lee et al. (2005) Job and industry classifications associated with sarcoidosis in A Case-Control Etiologic Study of Sarcoidosis (ACCESS). J Occup Environ Med 47:226-34 |
| Rybicki, Benjamin A; Walewski, Jose L; Maliarik, Mary J et al. (2005) The BTNL2 gene and sarcoidosis susceptibility in African Americans and Whites. Am J Hum Genet 77:491-9 |
| Newman, Lee S; Rose, Cecile S; Bresnitz, Eddy A et al. (2004) A case control etiologic study of sarcoidosis: environmental and occupational risk factors. Am J Respir Crit Care Med 170:1324-30 |
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