The objective of this study is to determine the prevalence and natural history of pulmonary and cardiac complications associated with HIV infection in utero, in infancy and during early childhood. The objective will be accomplished by establishing a prospective multicenter collaborative study. The study will include the following categories of patients: 1) infants and young children with symptomatic HIV infection acquired by the prenatal route (35 subjects); 2) newborn of women in whom HIV antibody tests were positive during pregnancy (mothers will be enrolled during pregnancy and pre- and post-natal course of infants will be followed--35 subjects). The subjects will be followed prospectively for 2 to 4 years. The types, incidence, course, and outcomes of pulmonary and cardiovascular disorders in these children will be determined. The resources of the Mount Sinai School of Medicine and its affiliated hospitals will be used to enhance recruitment. Coordination with other AIDS trials in women and children carried out in this institution will be attempted to maximize recruitment. The program will be divided into three phases. In Phase I, the protocol and data forms will be developed (1 year). Phase II will be the period of recruitment, study and follow up of the subjects (4 1/2 years). Phase III will involve data analysis (1 year).

Agency
National Institute of Health (NIH)
Institute
Division of Lung Diseases (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HR096042-006
Application #
2317490
Study Section
Project Start
1989-05-22
Project End
1995-05-21
Budget Start
1991-06-21
Budget End
1992-02-14
Support Year
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Pediatrics
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10029
Fisher, Stacy D; Easley, Kirk A; Orav, E John et al. (2005) Mild dilated cardiomyopathy and increased left ventricular mass predict mortality: the prospective P2C2 HIV Multicenter Study. Am Heart J 150:439-47
Geromanos, Kimberly; Sunkle, Susan N; Mauer, Mary Beth et al. (2004) Successful techniques for retaining a cohort of infants and children born to HIV-infected women: the prospective P2C2 HIV study. J Assoc Nurses AIDS Care 15:48-57
Perez-Atayde, A R; Kearney, D I; Bricker, J T et al. (2004) Cardiac, aortic, and pulmonary arteriopathy in HIV-infected children: the Prospective P2C2 HIV Multicenter Study. Pediatr Dev Pathol 7:61-70
Koumbourlis, Anastassios C; Chen, Xin C; Rao, J Sunil et al. (2004) Maximal expiratory flow at FRC (V'maxFRC): Methods of selection and differences in reported values. Pediatr Pulmonol 37:318-23
Kearney, Debra L; Perez-Atayde, Antonio R; Easley, Kirk A et al. (2003) Postmortem cardiomegaly and echocardiographic measurements of left ventricular size and function in children infected with the human immunodeficiency virus. The Prospective P2C2 HIV Multicenter Study. Cardiovasc Pathol 12:140-8
Rivenes, Shannon M; Colan, Steven D; Easley, Kirk A et al. (2003) Usefulness of the pediatric electrocardiogram in detecting left ventricular hypertrophy: results from the Prospective Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection (P2C2 HIV) multicenter study. Am Heart J 145:716-23
Lipshultz, Steven E; Easley, Kirk A; Orav, E John et al. (2002) Cardiovascular status of infants and children of women infected with HIV-1 (P(2)C(2) HIV): a cohort study. Lancet 360:368-73
Starc, Thomas J; Lipshultz, Steven E; Easley, Kirk A et al. (2002) Incidence of cardiac abnormalities in children with human immunodeficiency virus infection: The prospective P2C2 HIV study. J Pediatr 141:327-34
Colin, A A; Sunil Rao, J; Chen, X C et al. (2001) Forced expiratory flow in uninfected infants and children born to HIV-infected mothers. Am J Respir Crit Care Med 163:865-73
Chinen, J; Easley, K A; Mendez, H et al. (2001) Decline of CD3-positive T-cell counts by 6 months of age is associated with rapid disease progression in HIV-1--infected infants. J Allergy Clin Immunol 108:265-8

Showing the most recent 10 out of 15 publications