Abstract

The Women's Health Initiative is a randomized controlled clinical trial conducted in 40 clinical centers across the United States addressing some of the most common causes of death, disability, and impaired quality of life in postmenopausal women ages 50-79: cardiovascular disease; breast and colon cancer; and osteoporosis. The three components of this disease prevention trial are: (1) hormone replacement therapy with a primary outcomes of coronary heart disease and stroke and secondary outcomes of hip and other fractures; (2) low fat dietary intervention with primary outcomes of breast cancer and colorectal cancer and a secondary outcome of coronary heart disease; and (3) calcium and vitamin D supplementation with a primary outcome of hip fractures and secondary outcomes of colorectal cancer and combined fractures. A concurrent observational study will provide estimates of health effects of known risk factors and new predictors for disease. Each clinical center will collect data through questionnaires and biological specimens over 8-12 years.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Women'S Health Initiative - Office of The Director Nih (WH)
Type
Research and Development Contracts (N01)
Project #
N01WH032109-014
Application #
6354002
Study Section
Project Start
1993-03-30
Project End
2005-09-14
Budget Start
2000-09-18
Budget End
2001-09-30
Support Year
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Gong, J; Nishimura, K K; Fernandez-Rhodes, L et al. (2018) Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI. Int J Obes (Lond) 42:384-390
Swica, Yael; Warren, Michelle P; Manson, JoAnn E et al. (2018) Effects of oral conjugated equine estrogens with or without medroxyprogesterone acetate on incident hypertension in the Women's Health Initiative hormone therapy trials. Menopause 25:753-761
Jo Hodonsky, Chani; Schurmann, Claudia; Schick, Ursula M et al. (2018) Generalization and fine mapping of red blood cell trait genetic associations to multi-ethnic populations: The PAGE Study. Am J Hematol :
Mahmoodi, Bakhtawar K; Cushman, Mary; Anne Næss, Inger et al. (2017) Association of Traditional Cardiovascular Risk Factors With Venous Thromboembolism: An Individual Participant Data Meta-Analysis of Prospective Studies. Circulation 135:7-16
Kato, Ikuko; Lane, Dorothy; Womack, Catherine R et al. (2017) Interaction between Nonsteroidal Anti-inflammatory Drugs and Low-fat Dietary Intervention on Colorectal Cancer Incidence; the Women's Health Initiative (WHI) Dietary Modification Trial. J Am Coll Nutr 36:462-469
Bassuk, Shari S; Manson, JoAnn E (2016) The timing hypothesis: Do coronary risks of menopausal hormone therapy vary by age or time since menopause onset? Metabolism 65:794-803
Klimentidis, Y C; Arora, A; Chougule, A et al. (2016) FTO association and interaction with time spent sitting. Int J Obes (Lond) 40:411-6
Zaslavsky, Oleg; Woods, Nancy F; LaCroix, Andrea Z et al. (2016) Identification of Risk Factors for Mortality and Poor-Quality-of-Life Survival in Frail Older Women Participating in the Women's Health Initiative Observational Study. J Am Geriatr Soc 64:831-7
Ehret, Georg B (see original citation for additional authors) (2016) The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat Genet 48:1171-1184
Klimentidis, Yann C; Bea, Jennifer W; Thompson, Patricia et al. (2016) Genetic Variant in ACVR2B Is Associated with Lean Mass. Med Sci Sports Exerc 48:1270-5

Showing the most recent 10 out of 121 publications