Abstract

The objectives of each Vanguard Clinical Center is to cooperate with the Clinical Coordinating Center in developing, implementing and refining the overall program to ensure its feasibility and optimize it operationally before the additional Clinical Centers commence recruitment. The Vanguard Clinical Centers are to assist in the development, testing and implementation of the forms/questionnaires and procedures needed to recruit a group of postmenopausal U.S. women age 50-79, randomize them to a number of interventions, ensure adherence and adequate follow-up, and collect and transmit data and biological samples as needed for the ascertainment of the outcomes of the Clinical Trial and Observational Study

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Women'S Health Initiative - Office of The Director Nih (WH)
Type
Research and Development Contracts (N01)
Project #
N01WH032120-004
Application #
2326652
Study Section
Project Start
1993-04-30
Project End
2005-09-14
Budget Start
1993-09-27
Budget End
1996-04-14
Support Year
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Family Medicine
Type
Schools of Arts and Sciences
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Culbertson, Vaughn L; Rahman, Shaikh E; Bosen, Grayson C et al. (2018) Implications of Off-Target Serotoninergic Drug Activity: An Analysis of Serotonin Syndrome Reports Using a Systematic Bioinformatics Approach. Pharmacotherapy 38:888-898
Kirwa, Kipruto; Eliot, Melissa N; Wang, Yi et al. (2014) Residential proximity to major roadways and prevalent hypertension among postmenopausal women: results from the Women's Health Initiative San Diego Cohort. J Am Heart Assoc 3:e000727
Gorodeski, Eiran Z; Ishwaran, Hemant; Kogalur, Udaya B et al. (2011) Use of hundreds of electrocardiographic biomarkers for prediction of mortality in postmenopausal women: the Women's Health Initiative. Circ Cardiovasc Qual Outcomes 4:521-32
Kripke, Daniel F; Langer, Robert D; Elliott, Jeffrey A et al. (2011) Mortality related to actigraphic long and short sleep. Sleep Med 12:28-33
Allison, Matthew A; Manson, Joann E; Aragaki, Aaron et al. (2010) Vasomotor symptoms and coronary artery calcium in postmenopausal women. Menopause 17:1136-45
Li, Rongling; O'Sullivan, Mary J; Robinson, Jennifer et al. (2009) Family history of myocardial infarction predicts incident coronary heart disease in postmenopausal women with diabetes: the Women's Health Initiative Observational Study. Diabetes Metab Res Rev 25:725-32
Allison, Matthew A; Manson, Joann E; Langer, Robert D et al. (2008) Oophorectomy, hormone therapy, and subclinical coronary artery disease in women with hysterectomy: the Women's Health Initiative coronary artery calcium study. Menopause 15:639-47
Phillips, Lawrence S; Langer, Robert D (2005) Postmenopausal hormone therapy: critical reappraisal and a unified hypothesis. Fertil Steril 83:558-66
Langer, Robert D; Pradhan, Aruna D; Lewis, Cora E et al. (2005) Baseline associations between postmenopausal hormone therapy and inflammatory, haemostatic, and lipid biomarkers of coronary heart disease. The Women's Health Initiative Observational Study. Thromb Haemost 93:1108-16
Hsia, Judith; Aragaki, Aaron; Bloch, Michael et al. (2004) Predictors of angina pectoris versus myocardial infarction from the Women's Health Initiative Observational Study. Am J Cardiol 93:673-8

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