The objective of this project is to synthesize and purify 0.4 mole or more of the peptide hormone atrial natriuretic peptide (ANP). This large scale solid phase peptide synthesis would be the first attempt to mass synthesize a peptide greater than 10 amino acids. Specifically, this project is aimed at developing the large quantity of the solid support resin which is needed for teh Fmoc peptide synthesis; preparing and analyzing a large quantity of Fmoc- tyrosine (otBu; and derivatizing the resin with the carboyl terminal amino acid of ANP, tyrosine.

Project Start
1987-09-15
Project End
Budget Start
1987-09-15
Budget End
1988-03-14
Support Year
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Peptide Laboratory, Inc.
Department
Type
DUNS #
City
Emeryville
State
CA
Country
United States
Zip Code
94608