This project is aimed at using the SV40 large T antigen to elucidate the mechanism(s) of cellular senescence in WI-38 cells. We intend to use the ability of SV40 large T antigen to induce DNA synthesis in senescent WI- 38 cells to study 3 aspects of cellular senescence: 1) the expression of the PCNA gene; 2) the roles of B-myb, IGF-1 receptor; and 3) the immortalization of HDF by a ts mutuant of SV40 large T antigen.
| Francis, Mary Kay; Appel, Stacia; Meyer, Christine et al. (2004) Loss of EPC-1/PEDF expression during skin aging in vivo. J Invest Dermatol 122:1096-105 |
| Pignolo, Robert J; Francis, Mary Kay; Rotenberg, Mitch O et al. (2003) Putative role for EPC-1/PEDF in the G0 growth arrest of human diploid fibroblasts. J Cell Physiol 195:12-20 |
| Cristofalo, Vincent J; Beck, Jeanne; Allen, R G (2003) Cell senescence: an evaluation of replicative senescence in culture as a model for cell aging in situ. J Gerontol A Biol Sci Med Sci 58:B776-9; discussion 779-81 |
| Torres, Claudio; Francis, Mary Kay; Lorenzini, Antonello et al. (2003) Metabolic stabilization of MAP kinase phosphatase-2 in senescence of human fibroblasts. Exp Cell Res 290:195-206 |
| Gerhard, Glenn S; Benko, Floyd A; Allen, R G et al. (2002) Mitochondrial DNA mutation analysis in human skin fibroblasts from fetal, young, and old donors. Mech Ageing Dev 123:155-66 |
| Mawal-Dewan, Madhu; Lorenzini, Antonello; Frisoni, Lorenza et al. (2002) Regulation of collagenase expression during replicative senescence in human fibroblasts by Akt-forkhead signaling. J Biol Chem 277:7857-64 |
| Macera-Bloch, Lisa; Houghton, JeanMarie; Lenahan, Melanie et al. (2002) Termination of lifespan of SV40-transformed human fibroblasts in crisis is due to apoptosis. J Cell Physiol 190:332-44 |
| Lorenzini, Antonello; Tresini, Maria; Mawal-Dewan, Madhu et al. (2002) Role of the Raf/MEK/ERK and the PI3K/Akt(PKB) pathways in fibroblast senescence. Exp Gerontol 37:1149-56 |
| Tresini, M; Lorenzini, A; Frisoni, L et al. (2001) Lack of Elk-1 phosphorylation and dysregulation of the extracellular regulated kinase signaling pathway in senescent human fibroblast. Exp Cell Res 269:287-300 |
| Lorenzini, A; Hrelia, S; Bordoni, A et al. (2001) Is increased arachidonic acid release a cause or a consequence of replicative senescence? Exp Gerontol 36:65-78 |
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