Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG000378-26
Application #
6267167
Study Section
Project Start
1998-01-01
Project End
1998-11-10
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
26
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Allegheny University of Health Sciences
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19129
Francis, Mary Kay; Appel, Stacia; Meyer, Christine et al. (2004) Loss of EPC-1/PEDF expression during skin aging in vivo. J Invest Dermatol 122:1096-105
Pignolo, Robert J; Francis, Mary Kay; Rotenberg, Mitch O et al. (2003) Putative role for EPC-1/PEDF in the G0 growth arrest of human diploid fibroblasts. J Cell Physiol 195:12-20
Cristofalo, Vincent J; Beck, Jeanne; Allen, R G (2003) Cell senescence: an evaluation of replicative senescence in culture as a model for cell aging in situ. J Gerontol A Biol Sci Med Sci 58:B776-9; discussion 779-81
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Macera-Bloch, Lisa; Houghton, JeanMarie; Lenahan, Melanie et al. (2002) Termination of lifespan of SV40-transformed human fibroblasts in crisis is due to apoptosis. J Cell Physiol 190:332-44
Lorenzini, Antonello; Tresini, Maria; Mawal-Dewan, Madhu et al. (2002) Role of the Raf/MEK/ERK and the PI3K/Akt(PKB) pathways in fibroblast senescence. Exp Gerontol 37:1149-56
Tresini, M; Lorenzini, A; Frisoni, L et al. (2001) Lack of Elk-1 phosphorylation and dysregulation of the extracellular regulated kinase signaling pathway in senescent human fibroblast. Exp Cell Res 269:287-300
Lorenzini, A; Hrelia, S; Bordoni, A et al. (2001) Is increased arachidonic acid release a cause or a consequence of replicative senescence? Exp Gerontol 36:65-78

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