Abstract

Core A: Administrative CoreThe Administrative Core will have the responsibility of overseeing the activities of the program and providingsupport for the interdisciplinary study of behavioral and neural plasticity in the aged. Research studies will includeexamining inflammation, gliosis, astrocytes, amyloid aggregation and intracellular accumulation. The Core willcoordinate the shared use of facilities, services, equipment and supplies by all projects in the program and willcoordinate the purchasing and maintenance of animals to meet the needs of all research operations. The Corewill also monitor the Tissue and Peptide Resource Core, as well as oversee the availability and access of theADRC database that incorporates clinical, neuropathological, neuroanatomical, and biochemical data on controland AD tissues. Additionally, the Core will be responsible for organizing meetings and colloquia, overseeingfinancial matters, and maintaining communication with other AD-related programs at UCI and the Alzheimer'sDisease Research Centers of Orange, Los Angeles and San Diego Counties. The Core will also assist in materialtransfer agreements and oversee animal use/protocols and IRB issues.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
2P01AG000538-29A1
Application #
7347984
Study Section
Special Emphasis Panel (ZAG1-ZIJ-3 (O2))
Project Start
1997-08-01
Project End
2013-03-31
Budget Start
1997-08-01
Budget End
2009-03-31
Support Year
29
Fiscal Year
2008
Total Cost
$89,083
Indirect Cost

  Institution

Name
University of California Irvine
Department
Type
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Prieto, G Aleph; Tong, Liqi; Smith, Erica D et al. (2018) TNF? and IL-1? but not IL-18 Suppresses Hippocampal Long-Term Potentiation Directly at the Synapse. Neurochem Res :
Sosna, Justyna; Philipp, Stephan; Albay 3rd, Ricardo et al. (2018) Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease. Mol Neurodegener 13:11
Tong, Liqi; Prieto, G Aleph; Cotman, Carl W (2018) IL-1? suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation. J Neuroinflammation 15:127
Hainsworth, A H; Lee, S; Foot, P et al. (2018) Super-resolution imaging of subcortical white matter using stochastic optical reconstruction microscopy (STORM) and super-resolution optical fluctuation imaging (SOFI). Neuropathol Appl Neurobiol 44:417-426
Krotee, Pascal; Griner, Sarah L; Sawaya, Michael R et al. (2018) Common fibrillar spines of amyloid-? and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors. J Biol Chem 293:2888-2902
Prieto, G Aleph; Cotman, Carl W (2017) On the road towards the global analysis of human synapses. Neural Regen Res 12:1586-1589
Chen, E Y; Chu, S; Gov, L et al. (2017) CD200 modulates macrophage cytokine secretion and phagocytosis in response to poly(lactic co-glycolic acid) microparticles and films. J Mater Chem B 5:1574-1584
Snigdha, Shikha; Yassa, Michael A; deRivera, Christina et al. (2017) Pattern separation and goal-directed behavior in the aged canine. Learn Mem 24:123-131
Hernandez, Michael X; Namiranian, Pouya; Nguyen, Eric et al. (2017) C5a Increases the Injury to Primary Neurons Elicited by Fibrillar Amyloid Beta. ASN Neuro 9:1759091416687871
Hatami, Asa; Monjazeb, Sanaz; Milton, Saskia et al. (2017) Familial Alzheimer's Disease Mutations within the Amyloid Precursor Protein Alter the Aggregation and Conformation of the Amyloid-? Peptide. J Biol Chem 292:3172-3185

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