Abstract

The proposed work represents an effort to study various aspects of the endocrinology of aging. Areas to be investigated include: relationship between gonadol hormone level and sexual behavior in the rat; effect of age on vitamin D receptors in intestinal calcium absorption in the rat; the cause of the deterioration in glucose tolerance associated with age; the effect of age on somatomedin concentrations, binding and action; relationship between age, glucose intolerance, and glycosylated hemoglobin concentrations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
2P01AG001312-07A1
Application #
3090566
Study Section
(GER)
Project Start
1979-07-01
Project End
1990-06-30
Budget Start
1986-07-01
Budget End
1987-06-30
Support Year
7
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Kalinyak, J E; Hoffman, A R; Perlman, A J (1991) Ontogeny of angiotensinogen mRNA and angiotensin II receptors in rat brain and liver. J Endocrinol Invest 14:647-53
Ceda, G P; Denti, L; Ceresini, G et al. (1991) The effects of aging on the secretion of the common alpha-subunit of the glycoprotein hormones in men. J Am Geriatr Soc 39:353-8
Meyer, T W; Morelli, E; Loon, N et al. (1990) Converting enzyme inhibition and glomerular size selectivity in diabetic nephropathy. J Am Soc Nephrol 1:S64-8
Myers, B D (1990) Pathophysiology of proteinuria in diabetic glomerular disease. J Hypertens Suppl 8:S41-6
Coulston, A M; Mandelbaum, D; Reaven, G M (1990) Dietary management of nursing home residents with non-insulin-dependent diabetes mellitus. Am J Clin Nutr 51:67-71
Morelli, E; Loon, N; Meyer, T et al. (1990) Effects of converting-enzyme inhibition on barrier function in diabetic glomerulopathy. Diabetes 39:76-82
Peabody, C A; Warner, M D; Markoff, E et al. (1990) Growth hormone response to growth hormone releasing hormone in depression and schizophrenia. Psychiatry Res 33:269-76
Tavangar, K; Hoffman, A R; Kraemer, F B (1990) A micromethod for the isolation of total RNA from adipose tissue. Anal Biochem 186:60-3
Loon, N; Shemesh, O; Morelli, E et al. (1989) Effect of angiotensin II infusion on the human glomerular filtration barrier. Am J Physiol 257:F608-14
Malloy, P J; Hochberg, Z; Pike, J W et al. (1989) Abnormal binding of vitamin D receptors to deoxyribonucleic acid in a kindred with vitamin D-dependent rickets, type II. J Clin Endocrinol Metab 68:263-9

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