Abstract

The core aims are to obtain and age normal and genetically altered mice for all projects except project 4. The core will handle the ordering, material transfer agreements, certifications, housing and shipping. The core will purchase young normal C57/Bl6 and BALB/c mice to age in the Scripps facility. The core will also be responsible for FACS screening animals that are being bred onto appropriate genetic backgrounds. Core B will also provide access and funds for use of the Scripps FACS facility.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG001743-23
Application #
6649893
Study Section
Project Start
2002-09-01
Project End
2003-08-31
Budget Start
Budget End
Support Year
23
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Boyman, Onur; Ramsey, Chris; Kim, David M et al. (2008) IL-7/anti-IL-7 mAb complexes restore T cell development and induce homeostatic T Cell expansion without lymphopenia. J Immunol 180:7265-75
Ramsey, Chris; Rubinstein, Mark P; Kim, David M et al. (2008) The lymphopenic environment of CD132 (common gamma-chain)-deficient hosts elicits rapid homeostatic proliferation of naive T cells via IL-15. J Immunol 180:5320-6
Jelley-Gibbs, Dawn M; Strutt, Tara M; McKinstry, K Kai et al. (2008) Influencing the fates of CD4 T cells on the path to memory: lessons from influenza. Immunol Cell Biol 86:343-52
Purton, Jared F; Tan, Joyce T; Rubinstein, Mark P et al. (2007) Antiviral CD4+ memory T cells are IL-15 dependent. J Exp Med 204:951-61
Rubinstein, Mark P; Kovar, Marek; Purton, Jared F et al. (2006) Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}. Proc Natl Acad Sci U S A 103:9166-71
Ishimaru, Naozumi; Kishimoto, Hidehiro; Hayashi, Yoshio et al. (2006) Regulation of naive T cell function by the NF-kappaB2 pathway. Nat Immunol 7:763-72
Boyman, Onur; Cho, Jae-Ho; Tan, Joyce T et al. (2006) A major histocompatibility complex class I-dependent subset of memory phenotype CD8+ cells. J Exp Med 203:1817-25
Surh, Charles D; Boyman, Onur; Purton, Jared F et al. (2006) Homeostasis of memory T cells. Immunol Rev 211:154-63
Kovar, Marek; Boyman, Onur; Shen, Xuefei et al. (2006) Direct stimulation of T cells by membrane vesicles from antigen-presenting cells. Proc Natl Acad Sci U S A 103:11671-6
Haynes, Laura; Eaton, Sheri M; Burns, Eve M et al. (2005) Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen. J Exp Med 201:845-51

Showing the most recent 10 out of 75 publications