Administrative Core The structure of the Einstein Aging Study (EAS) is efficient and highly effective as demonstrated by our 20+ years of productivity. The Administrative Core provides the foundation for this structure and plays a central role in: fostering cohesion among the research sites, cores, projects and investigators; coordinating all project- related activities; promoting EAS growth and innovation; and ensuring that EAS meets its objectives. Drs. Richard Lipton (Einstein) and Martin Sliwinski (PSU) will share EAS administrative and scientific leadership in this PPG, reflecting the new focus on ambulatory methods. The Administrative Core is responsible for management of study resources, integrating scientific research goals of the Einstein Aging Study Program Project, serving as a liaison with collaborators, recruitment and follow-up of study participants, and working with the Clinical Core to triage subjects to the various projects. These functions are carried out in cooperation with four established committees. The Administrative Core works with the Long Term Planning Committee to establish programmatic priorities, allocate resources to meet individual project goals and coordinate the sharing of resources across projects. With the Scientific/ Administrative Committee, the Core monitors subject recruitment and retention, supervises data management, reviews scientific advances and progress at regular meetings, promotes scientific collaborations with other Einstein aging programs, and oversees the sharing of resources with investigators at other institutions. This Core will also coordinate data collection and communication within the EAS sites (Pennsylvania State University, the Mayo Clinic-Jacksonville, University of Miami and Columbia University). With the Fiscal Oversight Committee, the Administrative Core manages budgets and personnel, and communicates with the Einstein administration. The Administrative Core relies on an External Advisory Committee to provide input regarding analytic approaches, and study procedures, and then is responsible for implementing their recommendations and suggestions. The Administrative Core manages the relationships of the EAS external to our institution. This includes the preparation of annual progress reports for the National Institute on Aging and the Einstein Committee on Clinical Investigations, fostering liaisons with community groups to enhance community relationships and study participation and providing outreach to the scientific community (e.g., seminars on best practices in ambulatory methods to promote use of these methods and replication of EAS findings). Finally, the Administrative Core is responsible for the recruitment and retention of a systematic community residing sample of older adults.

Public Health Relevance

The Administrative Core is responsible for coordinating administrative, scientific, and fiscal activities of the Program Project. Given the multidisciplinary nature of this Program Project and the complexity of successfully following a large cohort of participants, strong leadership and teamwork is necessary for our success. A major strength of this Core is its ability to facilitate efficient and effective sharing of data from the Einstein Aging Study (EAS), a long-term well characterized cohort, through internal and external collaborations. These collabirations will expand the utility of this valuable database by increasing the availability of the high quality EAS data to the broader aging research community.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG003949-36
Application #
9744524
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2019-06-01
Budget End
2020-05-31
Support Year
36
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Type
DUNS #
081266487
City
Bronx
State
NY
Country
United States
Zip Code
10461
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Sliwinski, Martin J; Mogle, Jacqueline A; Hyun, Jinshil et al. (2018) Reliability and Validity of Ambulatory Cognitive Assessments. Assessment 25:14-30
Zammit, Andrea R; Robitaille, Annie; Piccinin, Andrea et al. (2018) Associations between aging-related changes in grip strength and cognitive function in older adults: A systematic review. J Gerontol A Biol Sci Med Sci :
Graham-Engeland, Jennifer E; Sin, Nancy L; Smyth, Joshua M et al. (2018) Negative and positive affect as predictors of inflammation: Timing matters. Brain Behav Immun 74:222-230
Hyun, Jinshil; Sliwinski, Martin J; Smyth, Joshua M (2018) Waking Up on the Wrong Side of the Bed: The Effects of Stress Anticipation on Working Memory in Daily Life. J Gerontol B Psychol Sci Soc Sci :
Li, Zeran; Del-Aguila, Jorge L; Dube, Umber et al. (2018) Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure. Genome Med 10:43
Majd, Marzieh; Graham-Engeland, Jennifer E; Smyth, Joshua M et al. (2018) Distinct inflammatory response patterns are evident among men and women with higher depressive symptoms. Physiol Behav 184:108-115
Bond, Dale S; Thomas, J Graham; Lipton, Richard B et al. (2018) Behavioral Weight Loss Intervention for Migraine: A Randomized Controlled Trial. Obesity (Silver Spring) 26:81-87
Zammit, Andrea R; Hall, Charles B; Katz, Mindy J et al. (2018) Class-Specific Incidence of All-Cause Dementia and Alzheimer's Disease: A Latent Class Approach. J Alzheimers Dis 66:347-357
Sun, Wenyan; Samimi, Hanie; Gamez, Maria et al. (2018) Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies. Nat Neurosci 21:1038-1048

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