The focus of the program project is on the behavioral and biomedical correlates of the clinical course of defined groups of individuals with (senile) demential of the Alzheimer type (SDAT/DAT) in comparison with the course of healthy aging. The psychometric core contributes to this effort by administering a battery of psychometric tests that assess memory (primary, secondary, semantic) as well as visuospatial and visuoconstructive, speeded psychomotor, sensory/motor, and language abilities. They are used to document the cognitive status of the research participants. These measures will also be related to clinical and neurapathological indices to determine the behavioral- neuropathological correlates in SDAT among the very old. They will also provide information about psychometric test performance in very late life in individuals who are not clinically demented. Psychometric test performance will be compared with data obtained from laboratory studies of memory processes to address the theoretical mechanisms underlying cognitive deficits in SDAT/DAT, especially very early in the course of the disease. Longitudinal changes in psychometric test performance will be compared with changes in hormone/metabolite changes, again in an effort to understand the mechanisms of the disease.
| Pottier, Cyril; Zhou, Xiaolai; Perkerson 3rd, Ralph B et al. (2018) Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. Lancet Neurol 17:548-558 |
| Joseph-Mathurin, Nelly; Su, Yi; Blazey, Tyler M et al. (2018) Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease. Alzheimers Dement (Amst) 10:669-677 |
| Del-Aguila, Jorge L; Fernández, Maria Victoria; Schindler, Suzanne et al. (2018) Assessment of the Genetic Architecture of Alzheimer's Disease Risk in Rate of Memory Decline. J Alzheimers Dis 62:745-756 |
| Oxtoby, Neil P; Young, Alexandra L; Cash, David M et al. (2018) Data-driven models of dominantly-inherited Alzheimer's disease progression. Brain 141:1529-1544 |
| Mishra, Shruti; Blazey, Tyler M; Holtzman, David M et al. (2018) Longitudinal brain imaging in preclinical Alzheimer disease: impact of APOE ?4 genotype. Brain 141:1828-1839 |
| Bonham, Luke W; Karch, Celeste M; Fan, Chun C et al. (2018) CXCR4 involvement in neurodegenerative diseases. Transl Psychiatry 8:73 |
| Schindler, Suzanne E; Gray, Julia D; Gordon, Brian A et al. (2018) Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging. Alzheimers Dement 14:1460-1469 |
| Wildburger, Norelle C; Gyngard, Frank; Guillermier, Christelle et al. (2018) Amyloid-? Plaques in Clinical Alzheimer's Disease Brain Incorporate Stable Isotope Tracer In Vivo and Exhibit Nanoscale Heterogeneity. Front Neurol 9:169 |
| Weintraub, Sandra; Besser, Lilah; Dodge, Hiroko H et al. (2018) Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS). Alzheimer Dis Assoc Disord 32:10-17 |
| Babulal, Ganesh M; Chen, Suzie; Williams, Monique M et al. (2018) Depression and Alzheimer's Disease Biomarkers Predict Driving Decline. J Alzheimers Dis 66:1213-1221 |
Showing the most recent 10 out of 911 publications
