Abstract

The Biostatistics Core will serve as a resource and collaborator for all projects related to this Program Project. In particular, the Biostatistics Core will consult on the statistical design of all projects and will consult on the application of appropriate statistical methodological techniques for all analyses. Staff of the Core will continue to be active collaborators in publications from this research. It will be responsible for collaboration in the design of all forms used, and will implement a data entry/data management procedures to achieve the most cost-effective computer utilization for the present and proposed studies. Methodologic developments will be pursued in constructing multivariate linear models for the cross-sectional/longitudinal data which are an important focus of the Program Project. New models for the spatial distribution of neuropathologic AD lesions will be developed in order to better understand the sampling errors characteristic of various protocols for quantifying AD markers.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
3P01AG003991-18S1
Application #
6481835
Study Section
Project Start
2001-08-01
Project End
2001-12-31
Budget Start
Budget End
Support Year
18
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Liao, Fan; Li, Aimin; Xiong, Monica et al. (2018) Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation. J Clin Invest 128:2144-2155
Jansen, Willemijn J; Ossenkoppele, Rik; Tijms, Betty M et al. (2018) Association of Cerebral Amyloid-? Aggregation With Cognitive Functioning in Persons Without Dementia. JAMA Psychiatry 75:84-95
Yan, Qi; Nho, Kwangsik; Del-Aguila, Jorge L et al. (2018) Genome-wide association study of brain amyloid deposition as measured by Pittsburgh Compound-B (PiB)-PET imaging. Mol Psychiatry :
Islam, Jyoti; Zhang, Yanqing (2018) Brain MRI analysis for Alzheimer's disease diagnosis using an ensemble system of deep convolutional neural networks. Brain Inform 5:2
Strain, Jeremy F; Smith, Robert X; Beaumont, Helen et al. (2018) Loss of white matter integrity reflects tau accumulation in Alzheimer disease defined regions. Neurology 91:e313-e318
Roe, Catherine M; Ances, Beau M; Head, Denise et al. (2018) Incident cognitive impairment: longitudinal changes in molecular, structural and cognitive biomarkers. Brain 141:3233-3248
Ogren, Jennifer A; Tripathi, Raghav; Macey, Paul M et al. (2018) Regional cortical thickness changes accompanying generalized tonic-clonic seizures. Neuroimage Clin 20:205-215
Ihara, Ryoko; Vincent, Benjamin D; Baxter, Michael R et al. (2018) Relative neuron loss in hippocampal sclerosis of aging and Alzheimer's disease. Ann Neurol 84:741-753
Deming, Yuetiva; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol 136:857-872
Sutphen, Courtney L; McCue, Lena; Herries, Elizabeth M et al. (2018) Longitudinal decreases in multiple cerebrospinal fluid biomarkers of neuronal injury in symptomatic late onset Alzheimer's disease. Alzheimers Dement 14:869-879

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