This project will address the need for a practical and valid assessment method which can be used by community physicians to enhance the recognition and diagnosis of dementia. The assessment method entitled the """"""""Brief Instrument for Dementia Detection (BIDD)"""""""" to be used in this project will contain specific items identified from our current longitudinal research studies which are determined to best discriminate dementia from nondemented aging. These items will be combined into a brief clinical assessment tool for use by practicing physicians. The long-term objective is to validate that successful informant-based research clinical assessment procedures can be adapted to improve detection of dementia in the community. Currently, dementia is underdiagnosed in the community. Community physicians overwhelming request the availability of clear, time efficient assessment protocols to aid the recognition of dementia. Specifically: 1. This project will develop a sensitive, portable dementia assessment instrument from key items derived from a collateral source-based research dementia protocol. 2. Health care professionals will be trained about dementia, dementia therapy, and the administration and interpretation of the brief assessment tool called BIDD through the newly established Urban Partner's Program. 3. The BIDD will be refined and tested for cultural sensitivity in a pilot study using a population-based sample enrolled in the """"""""Physical frailty in urban African Americans"""""""". 4. Evaluate the efficacy of the BIDD in detecting dementia in older adults (75 years old or older) by studying the change from baseline in the frequency of dementia diagnosis and treatment in St. Louis County Health Center patients and the increased request for dementia services from the Alzheimers Association. Also validity of the BIDD will studied by evaluating a randomly selected subset of Health Center patients and the population-based research subject sample with our research dementia assessment protocol to yield a """"""""gold standard"""""""" diagnosis of dementia for comparison with the BIDD-derived diagnosis.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG003991-25
Application #
7570049
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2008-01-01
Budget End
2008-12-31
Support Year
25
Fiscal Year
2008
Total Cost
$111,688
Indirect Cost
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Liao, Fan; Li, Aimin; Xiong, Monica et al. (2018) Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation. J Clin Invest 128:2144-2155
Jansen, Willemijn J; Ossenkoppele, Rik; Tijms, Betty M et al. (2018) Association of Cerebral Amyloid-? Aggregation With Cognitive Functioning in Persons Without Dementia. JAMA Psychiatry 75:84-95
Yan, Qi; Nho, Kwangsik; Del-Aguila, Jorge L et al. (2018) Genome-wide association study of brain amyloid deposition as measured by Pittsburgh Compound-B (PiB)-PET imaging. Mol Psychiatry :
Islam, Jyoti; Zhang, Yanqing (2018) Brain MRI analysis for Alzheimer's disease diagnosis using an ensemble system of deep convolutional neural networks. Brain Inform 5:2
Strain, Jeremy F; Smith, Robert X; Beaumont, Helen et al. (2018) Loss of white matter integrity reflects tau accumulation in Alzheimer disease defined regions. Neurology 91:e313-e318
Roe, Catherine M; Ances, Beau M; Head, Denise et al. (2018) Incident cognitive impairment: longitudinal changes in molecular, structural and cognitive biomarkers. Brain 141:3233-3248
Ogren, Jennifer A; Tripathi, Raghav; Macey, Paul M et al. (2018) Regional cortical thickness changes accompanying generalized tonic-clonic seizures. Neuroimage Clin 20:205-215
Ihara, Ryoko; Vincent, Benjamin D; Baxter, Michael R et al. (2018) Relative neuron loss in hippocampal sclerosis of aging and Alzheimer's disease. Ann Neurol 84:741-753
Deming, Yuetiva; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol 136:857-872
Sutphen, Courtney L; McCue, Lena; Herries, Elizabeth M et al. (2018) Longitudinal decreases in multiple cerebrospinal fluid biomarkers of neuronal injury in symptomatic late onset Alzheimer's disease. Alzheimers Dement 14:869-879

Showing the most recent 10 out of 911 publications