This project has three areas of investigation. The applicant proposes initially to study the development of electron dense pigmentary granules which appear in neurons following the digestion of retroviruses by phagosomes. He will also examine the induction of amyloid and neuritic plaques which occurs following the infection of VM mice by the 87A strain of the scrapie agent. These studies will concentrate on the origin, evolution and nature of the amyloid components of the induced plaques. He also proposes to elute immunoglobulins from autopsy-derived Alzheimer diseased brains. Finally, it is noted that the investigator and his associates will provide a considerable amount of support (morphologic evaluations) to the other projects of this proposed program. The techniques involve electron microscopy, immunoelectron microscopy, and immunohistochemistry.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG004342-05
Application #
3821652
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
San Diego
State
CA
Country
United States
Zip Code
92037
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