1) The factors influencing T delta induction in mice and humans and the possibility that IgD may be used to augment antibody production in aged mice, perhaps in combination with IL-2. Memory B cell development and its T cell regulation in aged and young mice will be compared (Drs. G.J. Thorbecke and R.F. Coico). 2) The surface properties, numbers and functional activity of Langerhans cells in the skin of aged and young mice and humans, and the upregulation of surface antigen expression (particularly Ia antigen) on these cells by lymphokines. The Ia expression on these antigen-presenting cells in the epidermis is greatly impaired with age and this may influence the balance of the helper to suppressor T cell in responses to antigen presented via skin and in the response to skin tumors (Drs. D.V. Belsito and G.J. Thobecke). 3) The functional activity and interrelation between various T cell subsets in the immune response of aged mice as related to cell surface properties. Further characterization of three different types of suppressor cells and enumeration of suppressor cell precursors (Dr. S.R.S. Gottesman). 4) The regenerative activity of prethymic cells in aged mice and the heterogeneity of these cells in terms of their surface receptors. Assessment of the ability of the thymus in aged mice to receive and propagate immigrant prothymocytes (Dr. R. Basch). 5) The chemotactic response, endothelial cell adherence, and generation of bactericidal oxygen metabolites by granulocytes from aged humans, as well as the influence of lymphokines an adenosine on these responses as related to cell membrane and cytoskeleton properties (Drs. B. Cronstein and R. Hirschhorn).

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
2P01AG004860-04
Application #
3090914
Study Section
Aging Review Committee (AGE)
Project Start
1984-08-01
Project End
1992-07-31
Budget Start
1987-08-01
Budget End
1988-07-31
Support Year
4
Fiscal Year
1987
Total Cost
Indirect Cost
Name
New York University
Department
Type
Schools of Medicine
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012
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Swenson, C D; Gottesman, S R; Belsito, D V et al. (1995) Relationship between humoral immunoaugmenting properties of DHEAS and IgD-receptor expression in young and aged mice. Ann N Y Acad Sci 774:249-58
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Fredrickson, G G; Basch, R S (1994) Early thymic regeneration after irradiation. Dev Comp Immunol 18:251-63
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Basch, R S; Oh, Y D; Saha, C S et al. (1992) Separation of self-renewing hematopoietic progenitors on the basis of CD45 (T-200) antigen expression. Exp Hematol 20:11-6
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Shin, S U; Wei, C F; Amin, A R et al. (1992) Structural and functional properties of mouse-human chimeric IgD. Hum Antibodies Hybridomas 3:65-74
Feiner, H D; Bannan, M; Marsh, E et al. (1992) Monoclonal gammopathy of undetermined significance: a morphologic and immunophenotypic study of the bone marrow. Mod Pathol 5:372-9
Epstein, S P; Baer, R L; Thorbecke, G J et al. (1991) Immunosuppressive effects of transforming growth factor beta: inhibition of the induction of Ia antigen on Langerhans cells by cytokines and of the contact hypersensitivity response. J Invest Dermatol 96:832-7

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