The Administrative and Biostatistics Core will provide the overall leadership as well as the infrastructure for the Program Project Grant (PPG). The five projects in the PPG represent independent but highly interactive proposals by experienced investigators who have a long track record of collaborative studies. A major goal of the Core, therefore, is to ensure optimal interaction and integration among the projects. These diverse projects also need the appropriate infrastructure and logistical support, such as sample acquisition and storage, data management, and central administrative coordination. Finally, throughout the history of this PPG, the Core has provided full-service statistical support to the investigators and trainees associated with the Projects. This is the only Core being requested in support of this PPG, owing in large part to the unique environment at Mayo, where institutional Cores provide much of the scientific infrastructure needed for these studies. Thus, the Specific Aims for the Administrative and Biostatistics Core are (1) To provide the administrative leadership for the PPG; (2) To provide the appropriate infrastructure for the conduct of the studies; and (3) To provide the biostatistical resources needed for the design and analysis of the studies.
Aim 1 is accomplished through an Administrative Committee, regular, planned meetings between the investigators, scientific oversight provided by an Advisory Committee that will convene annually, and a structure for mentoring of research fellows and junior faculty.
Aim 2 is accomplished by a dedicated sample processing and data management team, along with administrative support.
Aim 3 relies on the expertise of a master's level statistician who has had a long-term participation in the PPG (Ms. Atkinson) and a data analyst. These individuals accomplish complex statistical functions and also provide statistical advice and support to each of the investigators. Collectively, the Administrative and Biostatistics Core is the underpinning of this highly successful endeavor. This is reflected, in part, by the unique ability of our group to combine knowledge gained from population-based epidemiology studies, intensive human investigation, animal studies, and basic bone biology. Moreover, the success of the infrastructure and biostatistical support is perhaps best reflected by the ongoing productivity of our group, thus making the sum clearly greater than the parts.
| Xu, Ming; Pirtskhalava, Tamar; Farr, Joshua N et al. (2018) Senolytics improve physical function and increase lifespan in old age. Nat Med 24:1246-1256 |
| Khosla, Sundeep; Farr, Joshua N; Kirkland, James L (2018) Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis. J Clin Endocrinol Metab 103:1282-1290 |
| Rocca, Walter A (2018) The future burden of Parkinson's disease. Mov Disord 33:8-9 |
| Rocca, Walter A; Gazzuola Rocca, Liliana; Smith, Carin Y et al. (2018) Personal, reproductive, and familial characteristics associated with bilateral oophorectomy in premenopausal women: A population-based case-control study. Maturitas 117:64-77 |
| Drake, Matthew T; Fenske, Jennifer S; Blocki, Frank A et al. (2018) Validation of a novel, rapid, high precision sclerostin assay not confounded by sclerostin fragments. Bone 111:36-43 |
| Laughlin-Tommaso, Shannon K; Khan, Zaraq; Weaver, Amy L et al. (2018) Cardiovascular and metabolic morbidity after hysterectomy with ovarian conservation: a cohort study. Menopause 25:483-492 |
| Farr, Joshua N; Weivoda, Megan M; Nicks, Kristy M et al. (2018) Osteoprotection Through the Deletion of the Transcription Factor Ror? in Mice. J Bone Miner Res 33:720-731 |
| Wenning, Gregor; Trojanowski, John Q; Kaufmann, Horacio et al. (2018) Is multiple system atrophy an infectious disease? Ann Neurol 83:10-12 |
| Kattah, Andrea G; Smith, Carin Y; Gazzuola Rocca, Liliana et al. (2018) CKD in Patients with Bilateral Oophorectomy. Clin J Am Soc Nephrol 13:1649-1658 |
| Khosla, Sundeep; Monroe, David G (2018) Regulation of Bone Metabolism by Sex Steroids. Cold Spring Harb Perspect Med 8: |
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