Abstract

The primary goal is to support the subprojects by supplying precise and accurate biochemical measurements of markers of bone formation and bone resorption, calcium-regulating hormones, calcium absorption, sex steroids, and IGF and growth hormone. Bone formation will be assessed by serum osteocalcin and serum bone alkaline phosphatase. Bone resorption will be assessed by serum tartrate resistant acid phosphatase, urinary deoxypyridinoline and urinary n-telopeptide crosslinks. Calcium-regulating hormones will be assessed by serum parathyroid hormone, serum 250H vitamin D, and serum 1,25(OH)2 vitamin D. Calcium absorption will be assessed from the specific activity in serum following an oral dose of stable calcium labeled with radiocalcium. The sex steroids will be assessed by serum estradiol, estrone sulphate, estrone, testosterone, androstenedione, dehydroepiandrosterone and dehydroepiandrosterone sulphate, and sex- hormone binding globulin. Growth hormone will be assessed by measurements of urinary growth hormone and serum IGF and IGF-BP3. The biochemistry core will also be responsible for ensuring that all biological samples are logged-in, processed and stored under optimal conditions; that assays are performed with precision and accuracy; that the data generated are entered in the biochemistry database and transferred in a timely fashion to the biostatistical core for merging with clinical variables for analysis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG005793-13
Application #
6234125
Study Section
Project Start
1997-09-15
Project End
1998-08-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
13
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202

  Publications

Hui, Siu L; Perkins, Anthony J; Harezlak, Jaroslaw et al. (2010) Velocities of bone mineral accrual in black and white American children. J Bone Miner Res 25:1527-35
Ruppel, Meghan E; Burr, David B; Miller, Lisa M (2006) Chemical makeup of microdamaged bone differs from undamaged bone. Bone 39:318-24
Mashiba, T; Hui, S; Turner, C H et al. (2005) Bone remodeling at the iliac crest can predict the changes in remodeling dynamics, microdamage accumulation, and mechanical properties in the lumbar vertebrae of dogs. Calcif Tissue Int 77:180-5
McCabe, Linda D; Martin, Berdine R; McCabe, George P et al. (2004) Dairy intakes affect bone density in the elderly. Am J Clin Nutr 80:1066-74
Day, J S; Ding, M; Bednarz, P et al. (2004) Bisphosphonate treatment affects trabecular bone apparent modulus through micro-architecture rather than matrix properties. J Orthop Res 22:465-71
Ding, M; Day, J S; Burr, D B et al. (2003) Canine cancellous bone microarchitecture after one year of high-dose bisphosphonates. Calcif Tissue Int 72:737-44
Burr, David B; Miller, Lisa; Grynpas, Marc et al. (2003) Tissue mineralization is increased following 1-year treatment with high doses of bisphosphonates in dogs. Bone 33:960-9
Burr, D B (2002) Targeted and nontargeted remodeling. Bone 30:2-4
Li, J; Mashiba, T; Burr, D B (2001) Bisphosphonate treatment suppresses not only stochastic remodeling but also the targeted repair of microdamage. Calcif Tissue Int 69:281-6
Mashiba, T; Turner, C H; Hirano, T et al. (2001) Effects of high-dose etidronate treatment on microdamage accumulation and biomechanical properties in beagle bone before occurrence of spontaneous fractures. Bone 29:271-8

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