Core - Biostatistics and Epidemiology

Hui, Siu L.

Abstract

The primary objective of the Biostatistics, Epidemiology and Administrative Core is to maintain a high level of statistical competency and uniform standards of measurements for the research projects and to administer the overall program project. This core will perform data management and analysis for the projects and other core. A relational database system is used to manage the data and increase the efficiency and accuracy of data flow. In addition, it will be responsible for the determinants of bone mass, anthropometrics, dietary intake of nutrients, and physical activity levels, as needed by the four projects. Research assistants performing anthropometric measurements will be retrained regularly. Individual dietary intake of calcium and caffeine nutrients will be quantified by the use of food frequency questionnaires. Questionnaires will be used to illicit activity levels from adults and children. Bone mass measurements for all projects will be performed by experienced technicians, using x-ray absorptiometry for vertebral, hip and total body scans as well as ultrasound measurements at the os calcis. Quality control experiments will be performed regularly. The Core will be responsible for the financial and overall administration of the entire program project.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Aging (NIA)
• Type: Research Program Projects (P01)
• Project #: 5P01AG005793-15
• Application #: 6200961
• Project Start: 1999-09-01
• Project End: 2002-08-31
• Budget Start: 1997-10-01
• Budget End: 1998-09-30
• Support Year: 15
• Fiscal Year: 1999

Institution

• Name: Indiana University-Purdue University at Indianapolis
• DUNS #: 005436803
• City: Indianapolis
• State: IN
• Country: United States
• Zip Code: 46202

Publications

Hui, Siu L; Perkins, Anthony J; Harezlak, Jaroslaw et al. (2010) Velocities of bone mineral accrual in black and white American children. J Bone Miner Res 25:1527-35

Ruppel, Meghan E; Burr, David B; Miller, Lisa M (2006) Chemical makeup of microdamaged bone differs from undamaged bone. Bone 39:318-24

Mashiba, T; Hui, S; Turner, C H et al. (2005) Bone remodeling at the iliac crest can predict the changes in remodeling dynamics, microdamage accumulation, and mechanical properties in the lumbar vertebrae of dogs. Calcif Tissue Int 77:180-5

McCabe, Linda D; Martin, Berdine R; McCabe, George P et al. (2004) Dairy intakes affect bone density in the elderly. Am J Clin Nutr 80:1066-74

Day, J S; Ding, M; Bednarz, P et al. (2004) Bisphosphonate treatment affects trabecular bone apparent modulus through micro-architecture rather than matrix properties. J Orthop Res 22:465-71

Ding, M; Day, J S; Burr, D B et al. (2003) Canine cancellous bone microarchitecture after one year of high-dose bisphosphonates. Calcif Tissue Int 72:737-44

Burr, David B; Miller, Lisa; Grynpas, Marc et al. (2003) Tissue mineralization is increased following 1-year treatment with high doses of bisphosphonates in dogs. Bone 33:960-9

Burr, D B (2002) Targeted and nontargeted remodeling. Bone 30:2-4

Li, J; Mashiba, T; Burr, D B (2001) Bisphosphonate treatment suppresses not only stochastic remodeling but also the targeted repair of microdamage. Calcif Tissue Int 69:281-6

Mashiba, T; Turner, C H; Hirano, T et al. (2001) Effects of high-dose etidronate treatment on microdamage accumulation and biomechanical properties in beagle bone before occurrence of spontaneous fractures. Bone 29:271-8