Abstract

B. Introduction This project propose to study the pathogenesis of Theiler's murine encephalitis virus (TMEV) in mice as a function of age. TMEV is an enterovirus and a natural pathogen of mice closely related to important human pathogens. The virus is known to establish persistent infection in mice and age appears to be a critical determinant of disease patterns. The information to be gathered during this study will potentially be of great benefit to our understanding and management of human diseases caused by enteroviruses. We propose to study the relationship of RNA virus pathogenesis and aging a different, yet equally challenging task as that of the DNA viral work being proposed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG007347-05
Application #
3790232
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Yang, Q; Sarnow, P (1997) Location of the internal ribosome entry site in the 5' non-coding region of the immunoglobulin heavy-chain binding protein (BiP) mRNA: evidence for specific RNA-protein interactions. Nucleic Acids Res 25:2800-7
Haller, A A; Sarnow, P (1997) In vitro selection of a 7-methyl-guanosine binding RNA that inhibits translation of capped mRNA molecules. Proc Natl Acad Sci U S A 94:8521-6
McBratney, S; Sarnow, P (1996) Evidence for involvement of trans-acting factors in selection of the AUG start codon during eukaryotic translational initiation. Mol Cell Biol 16:3523-34
Levin, M J; Murray, M; Zerbe, G O et al. (1994) Immune responses of elderly persons 4 years after receiving a live attenuated varicella vaccine. J Infect Dis 170:522-6
Hayward, A R; Buda, K; Levin, M J (1994) Immune response to secondary immunization with live or inactivated VZV vaccine in elderly adults. Viral Immunol 7:31-6
Zhang, Y; Cosyns, M; Levin, M J et al. (1994) Cytokine production in varicella zoster virus-stimulated limiting dilution lymphocyte cultures. Clin Exp Immunol 98:128-33
Hayward, A R; Zerbe, G O; Levin, M J (1994) Clinical application of responder cell frequency estimates with four years of follow up. J Immunol Methods 170:27-36
Oh, S K; Sarnow, P (1993) Gene regulation: translational initiation by internal ribosome binding. Curr Opin Genet Dev 3:295-300
Mahalingam, R; Wellish, M; Lederer, D et al. (1993) Quantitation of latent varicella-zoster virus DNA in human trigeminal ganglia by polymerase chain reaction. J Virol 67:2381-4
Abzug, M J (1993) Identification of trophoblastic giant cells as the initial principal target of early gestational murine enterovirus infection. Placenta 14:137-48

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