The proposed Statistics and Data Management Core for the Program Project will provide unified computational and analytic resources for successful data collection, storage, linkage, and analysis for all of the projects in the Program Project. The proposed core will have both a data management component and a statistical analysis component. The goals of the data management portion of the core: 1) extraction of information from Alzheimer's Disease Clinical Core for databases and provision of reports on numbers of suitable subjects, 2) management of data collected by projects and cores specifically for this Program Project Grant, 3) systems for linking variables among project and cores and 4) documenting and maintaining the data library for this Program Project grant. The design advice, statistical programming, and methodologic expertise. The research goals of this Program Project present complexities in both the management and the analysis of the data. Data management will be complicated because of the large quantify of data from which focused variables are to be selected and because of the longitudinal nature of the clinical visits, with repeated return visits sought. Experience with data management, statistics, and with the clinical conduct of longitudinal studied in aged populations will provide expert support to the Program Project.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
2P01AG009466-11
Application #
6500979
Study Section
Project Start
1991-04-01
Project End
2004-03-31
Budget Start
Budget End
Support Year
11
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Rush University Medical Center
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60612
Mahady, Laura J; Perez, Sylvia E; Emerich, Dwaine F et al. (2017) Cholinergic profiles in the Goettingen miniature pig (Sus scrofa domesticus) brain. J Comp Neurol 525:553-573
Cade, Brian E; Gottlieb, Daniel J; Lauderdale, Diane S et al. (2016) Common variants in DRD2 are associated with sleep duration: the CARe consortium. Hum Mol Genet 25:167-79
Mufson, Elliott J; Malek-Ahmadi, Michael; Perez, Sylvia E et al. (2016) Braak staging, plaque pathology, and APOE status in elderly persons without cognitive impairment. Neurobiol Aging 37:147-153
Lim, Andrew S P; Bennett, David A; Buchman, Aron S (2016) Response to Letter Regarding Article, ""Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People"". Stroke 47:e175
Lim, Andrew S P; Yu, Lei; Schneider, Julie A et al. (2016) Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People. Stroke 47:516-8
Perez, Sylvia E; He, Bin; Nadeem, Muhammad et al. (2015) Resilience of precuneus neurotrophic signaling pathways despite amyloid pathology in prodromal Alzheimer's disease. Biol Psychiatry 77:693-703
Ramanan, Vijay K; Risacher, Shannon L; Nho, Kwangsik et al. (2015) GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP. Brain 138:3076-88
Beckett, Laurel A; Donohue, Michael C; Wang, Cathy et al. (2015) The Alzheimer's Disease Neuroimaging Initiative phase 2: Increasing the length, breadth, and depth of our understanding. Alzheimers Dement 11:823-31
Sohail, Shahmir; Yu, Lei; Bennett, David A et al. (2015) Irregular 24-hour activity rhythms and the metabolic syndrome in older adults. Chronobiol Int 32:802-13
Alldred, Melissa J; Lee, Sang Han; Petkova, Eva et al. (2015) Expression profile analysis of hippocampal CA1 pyramidal neurons in aged Ts65Dn mice, a model of Down syndrome (DS) and Alzheimer's disease (AD). Brain Struct Funct 220:2983-96

Showing the most recent 10 out of 197 publications