The Core includes three components: 1) Administration; 2) Animal Resource; and 3) Data Management. The Administrative component maintains a network of communication among the individual projects and between the projects and Core activities. This includes providing material/animals from the Animal Resource to the component projects and transfer of results from project experiments to a centralized Data Management System. Administrative responsibilities also include organizing and implementing regular meetings. Of the entire Program Project, along with its scientific advisory panel. The Animal Resource is a pathogen-free vivarium of aged Long-Evans male rats located at UNC-CH. Behavioral characterization of all aged rats used for neurobiological studies in the component projects will be conducted. Substantial background research presented in the proposal serves as a basis for examining spatial learning as an assessment of cognitive function which predicts aging in hippocampal/cortical circuitry. The final component of the Core, Data Management, provides services to the Program in its data collection and analysis activities. This includes: 1) consultation with participants regarding study design, routine and non-routine analyses, and power calculations; 2) design and maintenance of centralized archives for data generated on the project, including inventory of the animal population, data coding and analytic file construction; and 3) development of linked databases to allow across- project analyses. The overall goal of Core activities is to maximize the benefit that can be gained by collaborative research in a program project configuration.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
2P01AG009973-07
Application #
6234292
Study Section
Project Start
1997-09-01
Project End
1998-08-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
7
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Haberman, Rebecca P; Koh, Ming Teng; Gallagher, Michela (2017) Heightened cortical excitability in aged rodents with memory impairment. Neurobiol Aging 54:144-151
Haberman, Rebecca P; Branch, Audrey; Gallagher, Michela (2017) Targeting Neural Hyperactivity as a Treatment to Stem Progression of Late-Onset Alzheimer's Disease. Neurotherapeutics 14:662-676
Posada-Duque, Rafael Andrés; Ramirez, Omar; Härtel, Steffen et al. (2017) CDK5 downregulation enhances synaptic plasticity. Cell Mol Life Sci 74:153-172
Gu, Yu; Tran, Trinh; Murase, Sachiko et al. (2016) Neuregulin-Dependent Regulation of Fast-Spiking Interneuron Excitability Controls the Timing of the Critical Period. J Neurosci 36:10285-10295
Wang, Hui; Ardiles, Alvaro O; Yang, Sunggu et al. (2016) Metabotropic Glutamate Receptors Induce a Form of LTP Controlled by Translation and Arc Signaling in the Hippocampus. J Neurosci 36:1723-9
Robitsek, Jonathan; Ratner, Marcia H; Stewart, Tara et al. (2015) Combined administration of levetiracetam and valproic acid attenuates age-related hyperactivity of CA3 place cells, reduces place field area, and increases spatial information content in aged rat hippocampus. Hippocampus 25:1541-55
Tomás Pereira, Inês; Gallagher, Michela; Rapp, Peter R (2015) Head west or left, east or right: interactions between memory systems in neurocognitive aging. Neurobiol Aging 36:3067-3078
Gallagher, Michela; Burwell, Rebecca; Burchinal, Margaret (2015) Severity of spatial learning impairment in aging: Development of a learning index for performance in the Morris water maze. Behav Neurosci 129:540-8
Mayse, Jeffrey D; Nelson, Geoffrey M; Avila, Irene et al. (2015) Basal forebrain neuronal inhibition enables rapid behavioral stopping. Nat Neurosci 18:1501-8
Castellano, James F; Fletcher, Bonnie R; Patzke, Holger et al. (2014) Reassessing the effects of histone deacetylase inhibitors on hippocampal memory and cognitive aging. Hippocampus 24:1006-16

Showing the most recent 10 out of 165 publications