Core-- Molecular

Van Eldik, Linda J.

Abstract

The Molecular Core will provide centralized, high quality, cost-effective services to each project. These services include preparation and characterization of recombinant S100beta and mutant S100 proteins, maintenance of rat C6 glioma cells and of cell lines containing an S100beta antisense gene, synthesis of oligodeoxynucleotides, and performance of radioimmunoassays for S100beta. A senior technician will handle the needs of the members of this program project and will participate in the maintenance of resources used by the program participants. The principal investigators of each subproject will consult in advance with the core scientific director who will assist the senior technician in the planning and execution of the analyses.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Aging (NIA)
• Type: Research Program Projects (P01)
• Project #: 1P01AG010208-01
• Application #: 3790535
• Support Year: 1
• Fiscal Year: 1992

Institution

• Name: New York University
• DUNS #: 004514360
• City: New York
• State: NY
• Country: United States
• Zip Code: 10012

Publications

Mrak, Robert E; Griffin, W Sue T (2005) Glia and their cytokines in progression of neurodegeneration. Neurobiol Aging 26:349-54

Sheng, J G; Mrak, R E; Jones, R A et al. (2001) Neuronal DNA damage correlates with overexpression of interleukin-1beta converting enzyme in APPV717F mice. Neurobiol Aging 22:895-902

Nicoll, J A; Mrak, R E; Graham, D I et al. (2000) Association of interleukin-1 gene polymorphisms with Alzheimer's disease. Ann Neurol 47:365-8

Russo, G L; van den Bos , C; Sutton, A et al. (2000) Phosphorylation of Cdc28 and regulation of cell size by the protein kinase CKII in Saccharomyces cerevisiae. Biochem J 351:143-50

Sheng, J G; Zhu, S G; Jones, R A et al. (2000) Interleukin-1 promotes expression and phosphorylation of neurofilament and tau proteins in vivo. Exp Neurol 163:388-91

Griffin, W S; Nicoll, J A; Grimaldi, L M et al. (2000) The pervasiveness of interleukin-1 in alzheimer pathogenesis: a role for specific polymorphisms in disease risk. Exp Gerontol 35:481-7

Zhu, S G; Sheng, J G; Jones, R A et al. (1999) Increased interleukin-1beta converting enzyme expression and activity in Alzheimer disease. J Neuropathol Exp Neurol 58:582-7

Karson, C N; Mrak, R E; Schluterman, K O et al. (1999) Alterations in synaptic proteins and their encoding mRNAs in prefrontal cortex in schizophrenia: a possible neurochemical basis for 'hypofrontality'. Mol Psychiatry 4:39-45

Nishi, M; Azmitia, E C (1999) Agonist- and antagonist-induced plasticity of rat 5-HT1A receptor in hippocampal cell culture. Synapse 31:186-95

Royston, M C; McKenzie, J E; Gentleman, S M et al. (1999) Overexpression of s100beta in Down's syndrome: correlation with patient age and with beta-amyloid deposition. Neuropathol Appl Neurobiol 25:387-93