Abstract

The objective of Core A is to organize and administrate the activities of the Program Project. The specific tasks include keeping track of personnel, ordering and monitoring purchase of supplies, equipment, and other expenses to include travel arrangements and review of the monthly financial reports on each project. Core A will also be responsible for arranging the group meetings, and writing up the meeting notes. Core A will also include a biostatistics group lead by Dr. Ronald Thomas that will provide expertise in biostatistics and manage a web-based database for the projects/core.

Public Health Relevance

Core A will provide administrative support and leadership in the interactions of the individual projects and cores for this program project, which will study the causes of Alzheimer's disease and to develop potential new treatments. This research will promote healthy cognitive aging by testing the effects of physical exercise on brain structure and function.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
2P01AG010435-17A2
Application #
7786574
Study Section
Special Emphasis Panel (ZAG1-ZIJ-6 (O4))
Project Start
Project End
Budget Start
2010-04-15
Budget End
2011-03-31
Support Year
17
Fiscal Year
2010
Total Cost
$126,919
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Nagahara, Alan H; Wilson, Bayard R; Ivasyk, Iryna et al. (2018) MR-guided delivery of AAV2-BDNF into the entorhinal cortex of non-human primates. Gene Ther 25:104-114
Chen, Zhijiang; Donnelly, Christopher R; Dominguez, Bertha et al. (2017) p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling. Cell Rep 21:707-720
Hirai, Maretoshi; Arita, Yoh; McGlade, C Jane et al. (2017) Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation. J Clin Invest 127:569-582
Overk, Cassia; Masliah, Eliezer (2017) Perspective on the calcium dyshomeostasis hypothesis in the pathogenesis of selective neuronal degeneration in animal models of Alzheimer's disease. Alzheimers Dement 13:183-185
Kratter, Ian H; Zahed, Hengameh; Lau, Alice et al. (2016) Serine 421 regulates mutant huntingtin toxicity and clearance in mice. J Clin Invest 126:3585-97
van den Hurk, Mark; Kenis, Gunter; Bardy, Cedric et al. (2016) Transcriptional and epigenetic mechanisms of cellular reprogramming to induced pluripotency. Epigenomics 8:1131-49
Biane, Jeremy S; Takashima, Yoshio; Scanziani, Massimo et al. (2016) Thalamocortical Projections onto Behaviorally Relevant Neurons Exhibit Plasticity during Adult Motor Learning. Neuron 89:1173-1179
Spencer, Brian; Desplats, Paula A; Overk, Cassia R et al. (2016) Reducing Endogenous ?-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model. J Neurosci 36:7971-84
Xu, Jiqing; de Winter, Fred; Farrokhi, Catherine et al. (2016) Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer's disease model. Sci Rep 6:31692
Spencer, Brian; Potkar, Rewati; Metcalf, Jeff et al. (2016) Systemic Central Nervous System (CNS)-targeted Delivery of Neuropeptide Y (NPY) Reduces Neurodegeneration and Increases Neural Precursor Cell Proliferation in a Mouse Model of Alzheimer Disease. J Biol Chem 291:1905-20

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