Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
3P01AG010514-07S1
Application #
6295597
Study Section
Project Start
1998-12-01
Project End
1999-05-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
7
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Type
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555
Hegde, Muralidhar L; Mantha, Anil K; Hazra, Tapas K et al. (2012) Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases. Mech Ageing Dev 133:157-68
Tann, Anne W; Boldogh, Istvan; Meiss, Gregor et al. (2011) Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repair. J Biol Chem 286:31975-83
Zhang, Haihong; Xie, Chenghui; Spencer, Horace J et al. (2011) Obesity and hepatosteatosis in mice with enhanced oxidative DNA damage processing in mitochondria. Am J Pathol 178:1715-27
Szczesny, Bartosz; Tann, Anne W; Mitra, Sankar (2010) Age- and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: Susceptibility of skeletal muscles to oxidative injury. Mech Ageing Dev 131:330-7
Szczesny, Bartosz; Tann, Anne W; Longley, Matthew J et al. (2008) Long patch base excision repair in mammalian mitochondrial genomes. J Biol Chem 283:26349-56
Szczesny, Bartosz; Mitra, Sankar (2005) Effect of aging on intracellular distribution of abasic (AP) endonuclease 1 in the mouse liver. Mech Ageing Dev 126:1071-8
Choksi, K B; Boylston, W H; Rabek, J P et al. (2004) Oxidatively damaged proteins of heart mitochondrial electron transport complexes. Biochim Biophys Acta 1688:95-101
Garg, Nisha; Gerstner, Arpad; Bhatia, Vandanajay et al. (2004) Gene expression analysis in mitochondria from chagasic mice: alterations in specific metabolic pathways. Biochem J 381:743-52
Szczesny, Bartosz; Hazra, Tapas K; Papaconstantinou, John et al. (2003) Age-dependent deficiency in import of mitochondrial DNA glycosylases required for repair of oxidatively damaged bases. Proc Natl Acad Sci U S A 100:10670-5
Bhakat, Kishor K; Izumi, Tadahide; Yang, Suk-Hoon et al. (2003) Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene. EMBO J 22:6299-309

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