Abstract

Cardiac mass has been reported to be increased with age in humans and other mammalian species (I-9). The myocardial response to acute pressure or volume overload, however, is characterized by less new cardiac hypertrophy in the senescent heart (9-11). We have observed that left ventricular response to acute hemodynamic stress in terms of protein synthesis, RNA synthesis and immediate early gene expression (c-fos and c-jun) are less in old compared to young adult rat hearts (11). We postulate that the mechanisms responsible for the age associated cardiac hypertrophy and the decreased myocardial response to hemodynamic stress include an altered program of gene expression that occurs with aging. During the five year period, we will examine both changes in myocardial structure and changes in myocardial gene expression as influenced by age.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG010829-04
Application #
6295600
Study Section
Project Start
1996-07-01
Project End
1999-06-30
Budget Start
Budget End
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Zhang, X; Azhar, G; Nagano, K et al. (2001) Differential vulnerability to oxidative stress in rat cardiac myocytes versus fibroblasts. J Am Coll Cardiol 38:2055-62
Levy, B R; Hausdorff, J M; Hencke, R et al. (2000) Reducing cardiovascular stress with positive self-stereotypes of aging. J Gerontol B Psychol Sci Soc Sci 55:P205-13
Azhar, G; Liu, L; Zhang, X et al. (1999) Influence of age on hypoxia/reoxygenation-induced DNA fragmentation and bcl-2, bcl-xl, bax and fas in the rat heart and brain. Mech Ageing Dev 112:5-25
Azhar, G; Gao, W; Liu, L et al. (1999) Ischemia-reperfusion in the adult mouse heart influence of age. Exp Gerontol 34:699-714
Spindler, M; Saupe, K W; Tian, R et al. (1999) Altered creatine kinase enzyme kinetics in diabetic cardiomyopathy. A(31)P NMR magnetization transfer study of the intact beating rat heart. J Mol Cell Cardiol 31:2175-89
Vijg, J (1999) Genetics of aging. Sponsored by Cold Spring Harbor Laboratory, 2-5 April 1998. Biochim Biophys Acta 1423:R1-12
Khrapko, K; Bodyak, N; Thilly, W G et al. (1999) Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions. Nucleic Acids Res 27:2434-41
Turner, N A; Xia, F; Azhar, G et al. (1998) Oxidative stress induces DNA fragmentation and caspase activation via the c-Jun NH2-terminal kinase pathway in H9c2 cardiac muscle cells. J Mol Cell Cardiol 30:1789-801
Flacker, J M; Cummings, V; Mach Jr, J R et al. (1998) The association of serum anticholinergic activity with delirium in elderly medical patients. Am J Geriatr Psychiatry 6:31-41
Vijg, J; van Steeg, H (1998) Transgenic assays for mutations and cancer: current status and future perspectives. Mutat Res 400:337-54

Showing the most recent 10 out of 23 publications