The goals of this Core are i) to obtain, preserve, examine, diagnose, and disseminate human braint issue from autopsies of patients with Alzheimer's disease, Down's syndrome, and head injury, as well as appropriate controls; and from the resected temporal lobe specimens from patients with chronic intractable temporal lobe epilepsy; ii) to perform patient genotyping; iii) to process, embed and section animal brain tissues for immunohistochemical investigations, and to provide neuropathological evaluations of these tissues; and iv) to provide electron microscopical evaluation of tissues and cell cultures. Continued achievements of these goals will enhance and facilitate achievement of the aims of the Projects in this Program Project. In this way, this Core will facilitate investigation of glial-neuronal relationships underlying early pathogenic events in the development of the neuropathological features of Alzheimer's disease.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
2P01AG012411-04A1
Application #
6098594
Study Section
Project Start
1999-06-01
Project End
2000-05-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Arkansas for Medical Sciences
Department
Type
DUNS #
City
Little Rock
State
AR
Country
United States
Zip Code
72205
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