Abstract

The goals of Core B are (/) to obtain, preserve, examine, diagnose, and disseminate human brain tissue from autopsies of patients with Alzheimer's disease (AD) and patients with Lewy body dementia (LBD) as well as appropriate controls;(if) process, embed, and section animal tissues and prepare tissue cultures generated by the projects for morphologic, immunohistochemical, and in situ hybridization characterization and investigation. Continued achievementof these goals will enhance and facilitate achievement of the aims of the Projects in this Program Project. In these ways, this Core will facilitate investigations of glial-neuronal relationships underlying early pathogenic events in the development of the neuropathologic features of AD.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG012411-15
Application #
8375477
Study Section
Special Emphasis Panel (ZAG1-ZIJ-2)
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
15
Fiscal Year
2012
Total Cost
$194,222
Indirect Cost
$55,132

  Institution

Name
University of Arkansas for Medical Sciences
Department
Type
DUNS #
122452563
City
Little Rock
State
AR
Country
United States
Zip Code
72205

  Publications

Kiaei, Mahmoud; Balasubramaniam, Meenakshisundaram; Govind Kumar, Vivek et al. (2018) ALS-causing mutations in profilin-1 alter its conformational dynamics: A computational approach to explain propensity for aggregation. Sci Rep 8:13102
Zafar, Maroof K; Maddukuri, Leena; Ketkar, Amit et al. (2018) A Small-Molecule Inhibitor of Human DNA Polymerase ? Potentiates the Effects of Cisplatin in Tumor Cells. Biochemistry 57:1262-1273
Janganati, Venumadhav; Ponder, Jessica; Balasubramaniam, Meenakshisundaram et al. (2018) MMB triazole analogs are potent NF-?B inhibitors and anti-cancer agents against both hematological and solid tumor cells. Eur J Med Chem 157:562-581
Ayyadevara, Srinivas; Ganne, Akshatha; Hendrix, Rachel D et al. (2018) Functional assessments through novel proteomics approaches: Application to insulin/IGF signaling in neurodegenerative disease'. J Neurosci Methods :
Balasubramaniam, Meenakshisundaram; Ayyadevara, Srinivas; Shmookler Reis, Robert J (2018) Structural insights into pro-aggregation effects of C. elegans CRAM-1 and its human ortholog SERF2. Sci Rep 8:14891
Liu, A K L; Lim, E J; Ahmed, I et al. (2018) Review: Revisiting the human cholinergic nucleus of the diagonal band of Broca. Neuropathol Appl Neurobiol 44:647-662
Lamture, Gauri; Crooks, Peter A; Borrelli, Michael J (2018) Actinomycin-D and dimethylamino-parthenolide synergism in treating human pancreatic cancer cells. Drug Dev Res 79:287-294
Balasubramaniam, Meenakshisundaram; Reis, Robert J Shmookler; Ayyadevara, Srinivas et al. (2017) Involvement of tRNAs in replication of human mitochondrial DNA and modifying effects of telomerase. Mech Ageing Dev 166:55-63
Barger, Steven W (2016) Gene regulation and genetics in neurochemistry, past to future. J Neurochem 139 Suppl 2:24-57
Mao, Xianrong; Phanavanh, Bounleut; Hamdan, Hamdan et al. (2016) NF?B-inducing kinase inhibits NF?B activity specifically in neurons of the CNS. J Neurochem 137:154-63

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