Abstract

Dr. Anders H. Andersen will direct the Data Analysis Core. Dr. Andersen has over 15 years experience in biomedical signal and image data analysis, especially in the area of MRI and fMRI data. He is familiar with the analysis of behavioral, neurochemical, morphological, and electrochemical endpoints taken on aging rhesus monkeys. Dr. Hardy will be in charge of developing new MRI sequences for MRI data acquisition and MRI measurements of iron content. He is an expert on medical physics, especially MRI. Dr. Rayens will be in charge of the statistical analysis for all major endpoints of the project as well as help with the correlation of responses among the projects and among measurements. He is an expert on biostatistics and applied multivariate statistical methods.
The specific aims of the Data Analysis Core are to: 1. advise all investigators in the Program Project on issues related to experimental design and data analysis, 2. perform the statistical analysis of the main endpoints in each of the projects, 3. provide quantitative assessments of each fMRI and anatomical MRI session recorded in Project by Zhang, and 4. correlate the findings among the projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG013494-10
Application #
7371011
Study Section
Special Emphasis Panel (ZAG1)
Project Start
2007-03-15
Project End
2008-01-31
Budget Start
2007-03-15
Budget End
2008-01-31
Support Year
10
Fiscal Year
2007
Total Cost
$64,606
Indirect Cost

  Institution

Name
University of Kentucky
Department
Type
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506

  Publications

Stenslik, M J; Evans, A; Pomerleau, F et al. (2018) Methodology and effects of repeated intranasal delivery of DNSP-11 in awake Rhesus macaques. J Neurosci Methods 303:30-40
Miller, Erin M; Quintero, Jorge E; Pomerleau, François et al. (2015) Simultaneous glutamate recordings in the frontal cortex network with multisite biomorphic microelectrodes: New tools for ADHD research. J Neurosci Methods 252:75-9
Stenslik, Mallory J; Potts, Lisa F; Sonne, James W H et al. (2015) Methodology and effects of repeated intranasal delivery of DNSP-11 in a rat model of Parkinson's disease. J Neurosci Methods 251:120-9
Fuqua, Joshua L; Littrell, Ofelia M; Lundblad, Martin et al. (2014) Dynamic changes in dopamine neuron function after DNSP-11 treatment: effects in vivo and increased ERK 1/2 phosphorylation in vitro. Peptides 54:1-8
Stephens, Michelle L; Williamson, Anne; Deel, Megan E et al. (2014) Tonic glutamate in CA1 of aging rats correlates with phasic glutamate dysregulation during seizure. Epilepsia 55:1817-25
Littrell, O M; Fuqua, J L; Richardson, A D et al. (2013) A synthetic five amino acid propeptide increases dopamine neuron differentiation and neurochemical function. Neuropeptides 47:43-9
Miller, Erin M; Pomerleau, Francois; Huettl, Peter et al. (2012) The spontaneously hypertensive and Wistar Kyoto rat models of ADHD exhibit sub-regional differences in dopamine release and uptake in the striatum and nucleus accumbens. Neuropharmacology 63:1327-34
Littrell, Ofelia M; Pomerleau, Francois; Huettl, Peter et al. (2012) Enhanced dopamine transporter activity in middle-aged Gdnf heterozygous mice. Neurobiol Aging 33:427.e1-14
Hinzman, Jason M; Thomas, Theresa Currier; Quintero, Jorge E et al. (2012) Disruptions in the regulation of extracellular glutamate by neurons and glia in the rat striatum two days after diffuse brain injury. J Neurotrauma 29:1197-208
Stephens, Michelle L; Quintero, Jorge E; Pomerleau, Francois et al. (2011) Age-related changes in glutamate release in the CA3 and dentate gyrus of the rat hippocampus. Neurobiol Aging 32:811-20

Showing the most recent 10 out of 65 publications