Abstract

The focus of this project is on the analysis of quantitative trait loci (QTLs) associated with length of life, or longevity, as a phenotype of aging. Although previous findings suggest that the upper range of heritability of longevity is about 0.30, the findings from these studies may be confounded by viral pathogens and so indicate genetic predisposition to disease rather than longevity. In this study, a pathogen-free barrier environment will be provided for 480 animals (10 males and 10 females, each of 22 RI stains and 2 progenitor strains) throughout their lives. In order to follow future post-mortem examination, animals will be examined at regular intervals throughout the day to retrieve individuals within a short time of expiration in order to prevent or minimize autolysis. QTL analysis based on the RI strain means will relate longevity to the genotypic strain distribution patterns. An advantage of the fixed genotype of the RIs is that it will allow relationships to be adduced between the biomarker phenotypes measured in other RI samples to that of longevity, providing correlation between the marker variables and length of life.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG014731-02
Application #
6299399
Study Section
Project Start
2000-03-01
Project End
2001-01-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
2
Fiscal Year
2000
Total Cost
$353,404
Indirect Cost

  Institution

Name
Pennsylvania State University
Department
Type
DUNS #
City
University Park
State
PA
Country
United States
Zip Code
16802

  Publications

Sandri, M; Barberi, L; Bijlsma, A Y et al. (2013) Signalling pathways regulating muscle mass in ageing skeletal muscle: the role of the IGF1-Akt-mTOR-FoxO pathway. Biogerontology 14:303-23
Ramamurthy, B; Larsson, L (2013) Detection of an aging-related increase in advanced glycation end products in fast- and slow-twitch skeletal muscles in the rat. Biogerontology 14:293-301
Sloane, Lauren B; Stout, Joseph T; Austad, Steven N et al. (2011) Tail tendon break time: a biomarker of aging? J Gerontol A Biol Sci Med Sci 66:287-94
Sloane, Lauren B; Stout, Joseph T; Vandenbergh, David J et al. (2011) Quantitative trait loci analysis of tail tendon break time in mice of C57BL/6J and DBA/2J lineage. J Gerontol A Biol Sci Med Sci 66:170-8
Lionikas, Arimantas; Carlborg, Orjan; Lu, Lu et al. (2010) Genomic analysis of variation in hindlimb musculature of mice from the C57BL/6J and DBA/2J lineage. J Hered 101:360-7
Lang, Dean H; Conroy, David E; Lionikas, Arimantas et al. (2009) Bone, muscle, and physical activity: structural equation modeling of relationships and genetic influence with age. J Bone Miner Res 24:1608-17
Blizard, David A; Lionikas, Arimantas; Vandenbergh, David J et al. (2009) Blood pressure and heart rate QTL in mice of the B6/D2 lineage: sex differences and environmental influences. Physiol Genomics 36:158-66
Foreman, J E; Lionikas, A; Lang, D H et al. (2009) Genetic architecture for hole-board behaviors across substantial time intervals in young, middle-aged and old mice. Genes Brain Behav 8:714-27
Norman, Holly; Zackrisson, Håkan; Hedström, Yvette et al. (2009) Myofibrillar protein and gene expression in acute quadriplegic myopathy. J Neurol Sci 285:28-38
Cristea, A; Korhonen, M T; Hakkinen, K et al. (2008) Effects of combined strength and sprint training on regulation of muscle contraction at the whole-muscle and single-fibre levels in elite master sprinters. Acta Physiol (Oxf) 193:275-89

Showing the most recent 10 out of 48 publications