Abstract

The Animal Resources Core (Core B) will provide young adult male and female rats of defined endocrine status after castration and sex steroid replacements. Depending on the study, castrated female rats will receive estradiol, Premarin, or constituents of Premarin (equilin). Aging male and female rats will be maintained for observation after receipt from the supplier. Necropsy records will be maintained on gross organ pathology, e.g. pituitary tumors, to evaluate individual differences in brain responses. Assays will be provided for rat plasma LH, estradiol, testosterone, and corticosterone. Transgenic mice (Project 1) will be bred to establish lines with GFAP promoter constructs engineered for altered responses to estradiol; these mice will also be used in Projects 2 and 4. Tissues will be distributed from hormone characterized rats and transgenic mice to the present projects, as well as to other USC colleagues who are studying estrogen effects on non-neural target tissues.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG014751-03
Application #
6098777
Study Section
Project Start
1999-08-01
Project End
2000-07-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Southern California
Department
Type
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Finch, Caleb E; Beltrán-Sánchez, Hiram; Crimmins, Eileen M (2014) Uneven futures of human lifespans: reckonings from Gompertz mortality rates, climate change, and air pollution. Gerontology 60:183-8
Baudry, M; Bi, X; Aguirre, C (2013) Progesterone-estrogen interactions in synaptic plasticity and neuroprotection. Neuroscience 239:280-94
Kim, Soyun; Wang, Miao; Lee, Amy S et al. (2011) Impaired eyeblink conditioning in 78 kDa-glucose regulated protein (GRP78)/immunoglobulin binding protein (BiP) conditional knockout mice. Behav Neurosci 125:404-11
Kim, Soyun; Thompson, Richard F (2011) c-Fos, Arc, and stargazin expression in rat eyeblink conditioning. Behav Neurosci 125:117-23
Dominguez, Reymundo; Hu, Eric; Zhou, Miou et al. (2009) 17beta-estradiol-mediated neuroprotection and ERK activation require a pertussis toxin-sensitive mechanism involving GRK2 and beta-arrestin-1. J Neurosci 29:4228-38
Thompson, Richard F (2009) Habituation: a history. Neurobiol Learn Mem 92:127-34
Micevych, Paul; Dominguez, Reymundo (2009) Membrane estradiol signaling in the brain. Front Neuroendocrinol 30:315-27
Brinton, Roberta Diaz (2009) Estrogen-induced plasticity from cells to circuits: predictions for cognitive function. Trends Pharmacol Sci 30:212-22
Wong, Angela M; Rozovsky, Irina; Arimoto, Jason M et al. (2009) Progesterone influence on neurite outgrowth involves microglia. Endocrinology 150:324-32
Lee, Ka Hung; Chatila, Talal A; Ram, Rana A et al. (2009) Impaired memory of eyeblink conditioning in CaMKIV KO mice. Behav Neurosci 123:438-42

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