Abstract

The administrative core will provide the support services which are necessary to the efficient functioning of the Program Project. Administrative as well as scientific coordination will be provided by the PI, Dr. Gary E. Gibson, and core members. Full staff meetings will be held regularly, to promote scientific interchange and coordination among the different Projects and Cores. These will include Drs. Beal and Starkov and their coworkers on the Manhattan Campus, as well as Drs. Ratan and Gibson in White Plains. A proportion of the meetings will be held in Westchester and at the Manhattan site (in conjunction with attendance at lectures of interest or other scientific presentations there), as well as by videoconferencing or web conferencing. Dr. Vahran Haroutunian will continue to provide human brain samples from the ADRC at Mt. Sinai. Annual review will be provided by an External Review Committee (ERC). The current members of the ERC will continue to serve and the expertise of the members of the ERC include genetic manipulation of cells and mice, enzymology, protein chemistry, metabolism, mitochondria and cell biology. The members of the ERC will also be available for more frequent ad hoc consultations on issues of their particular expertise. The core will also provide hIPSC that have the tau mutations, assist in the development of new virus's and new mice.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
2P01AG014930-15A1
Application #
8999502
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2016-04-15
Budget End
2017-03-31
Support Year
15
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
Winifred Masterson Burke Med Research Institute
Department
Type
DUNS #
780676131
City
White Plains
State
NY
Country
United States
Zip Code
10605

  Publications

Tapias, Victor; Jainuddin, Shari; Ahuja, Manuj et al. (2018) Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy. Hum Mol Genet 27:2874-2892
Garg, Ankur; Hannan, Abdul; Wang, Qian et al. (2018) FGF-induced Pea3 transcription factors program the genetic landscape for cell fate determination. PLoS Genet 14:e1007660
Franich, Nicholas R; Basso, Manuela; André, Emily A et al. (2018) Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models. J Huntingtons Dis 7:137-150
Karuppagounder, Saravanan S; Zhai, Yujia; Chen, Yingxin et al. (2018) The interferon response as a common final pathway for many preconditioning stimuli: unexpected crosstalk between hypoxic adaptation and antiviral defense. Cond Med 1:143-150
Shurubor, Yevgeniya I; D'Aurelio, Marilena; Clark-Matott, Joanne et al. (2017) Determination of Coenzyme A and Acetyl-Coenzyme A in Biological Samples Using HPLC with UV Detection. Molecules 22:
Zille, Marietta; Karuppagounder, Saravanan S; Chen, Yingxin et al. (2017) Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis. Stroke 48:1033-1043
Gibson, Gary E; Thakkar, Ankita (2017) Interactions of Mitochondria/Metabolism and Calcium Regulation in Alzheimer's Disease: A Calcinist Point of View. Neurochem Res 42:1636-1648
Gureev, Artem P; Shaforostova, Ekaterina A; Starkov, Anatoly A et al. (2017) Simplified qPCR method for detecting excessive mtDNA damage induced by exogenous factors. Toxicology 382:67-74
Ratan, Rajiv R (2017) Building on NeuroNEXT: Next generation clinics to cure chronic neurological disability. Ann Neurol 82:859-862
Starkov, Anatoly A; Chinopoulos, Christos; Starkova, Natalia N et al. (2017) Divalent cation chelators citrate and EDTA unmask an intrinsic uncoupling pathway in isolated mitochondria. J Bioenerg Biomembr 49:3-11

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