Abstract

The animal core will provide program project investigators with access to aged rhesus macaques and an extensive biomarker database. A colony of thirty aged female rhesus and additional young control females will be maintained in the California Regional Primate Research Center for behavioral and neuroanatomical studies. The biomarker data base will include daily determination of menses cycle activity, monitoring of reproductive hormone metabolites in the urine, serum hormone levels, and routine clinical parameters such as complete blood counts, serum chemistries, and urinalysis. For study designs which require ovariectomized animals, the animal core will perform bilateral ovarictomies on aged females or young controls, and estradiol replacement, and conditioning for animal handling and transport. Macaque reproductive and physiological parameters will be provided to Core Band made easily accessible to all investigators for experimental analysis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
1P01AG016765-01
Application #
6098860
Study Section
Project Start
1999-04-21
Project End
2000-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Mount Sinai School of Medicine
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Baxter, Mark G; Santistevan, Anthony C; Bliss-Moreau, Eliza et al. (2018) Timing of cyclic estradiol treatment differentially affects cognition in aged female rhesus monkeys. Behav Neurosci 132:213-223
Crimins, Johanna L; Puri, Rishi; Calakos, Katina C et al. (2018) Synaptic distributions of pS214-tau in rhesus monkey prefrontal cortex are associated with spine density, but not with cognitive decline. J Comp Neurol :
Milham, Michael P; Ai, Lei; Koo, Bonhwang et al. (2018) An Open Resource for Non-human Primate Imaging. Neuron 100:61-74.e2
Motley, Sarah E; Grossman, Yael S; Janssen, William G M et al. (2018) Selective Loss of Thin Spines in Area 7a of the Primate Intraparietal Sulcus Predicts Age-Related Working Memory Impairment. J Neurosci 38:10467-10478
Bliss-Moreau, Eliza; Baxter, Mark G (2018) Estradiol treatment in a nonhuman primate model of menopause preserves affective reactivity. Behav Neurosci 132:224-229
Garcia, Alexandra N; Depena, Christina; Bezner, Kelsey et al. (2018) The timing and duration of estradiol treatment in a rat model of the perimenopause: Influences on social behavior and the neuromolecular phenotype. Horm Behav 97:75-84
Beckman, Danielle; Baxter, Mark G; Morrison, John H (2018) Future directions in animal models of Alzheimer's disease. J Neurosci Res 96:1829-1830
McEwen, Bruce S; Milner, Teresa A (2017) Understanding the broad influence of sex hormones and sex differences in the brain. J Neurosci Res 95:24-39
Nutsch, Victoria L; Bell, Margaret R; Will, Ryan G et al. (2017) Aging and estradiol effects on gene expression in the medial preoptic area, bed nucleus of the stria terminalis, and posterodorsal medial amygdala of male rats. Mol Cell Endocrinol 442:153-164
Garcia, Alexandra N; Bezner, Kelsey; Depena, Christina et al. (2017) The effects of long-term estradiol treatment on social behavior and gene expression in adult female rats. Horm Behav 87:145-154

Showing the most recent 10 out of 132 publications