The University of Missouri-Columbia (MU) Program Project Grant (PPG), Cell Models for AD: Lipids andRelated Signaling Pathways, is a comprehensive research and training program that investigates the impactof oxidative stress and oligomeric Ap on neuronal dysfunction and chronic inflammation using appropriatecell and animal models that express different phenotypes of AD. The Administrative Core is a keycomponent for the success of the PPG. The overall goal of the Administrative Core, led by Grace Y. Sun,PhD, is to provide cohesiveness to the PPG by overseeing and supervising Research Projects and Cores.This effort includes, but is not limited to, the administration of the budget and high cost resources, thecoordination of visits by invited speakers, the organization of meetings for the internal and external advisoryboards, and interactions with other NIA- funded investigators conducting research on Alzheimer's diseaseand NIA Program Officers. The PPG is comprised of three highly integrated projects and two cores.
Specificaims for Core A are: 1) Coordinate and oversee the PPG administrative activities; 2) Foster interactionsamong PPG researchers; 3) Organize a seminar series to focus on AD and related subjects; 4) Providestatistical consultations; 5) Provide emergency funds for equipment repair or replacement of smallequipment; 6) Design a website for the PPG; 7) Establish the Advisory Committee; and 8) Organize nationaland international symposia and meetings of the PPG Executive Committee. With the exception of partialsupport for personnel, major support for Administrative Core A is through a grant from the University ofMissouri-Columbia PRIME Fund. MU will provide funds to establish new educational activities by supportingvisits of seminar speakers to the MU campus, by organizing local, national and international symposia thatwill enhance research on the pathogenesis of AD, and by promoting innovative strategies for the preventionand retardation of disease progression.
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