Abstract

Age-related osteoporotic fractures are largely due to an increased propensity to fall and an increase in bone fragility due to a reduction in bone strength with aging. Several factors contribute to bone strength including bone mineral density (BMD), bone structure, bone quality and bone turnover, all four of which have phenotypes that are highly heritable. The long-term goal of this application is to identify genes that underlie bone fragility using the positional cloning/candidate approach. The first step to attaining this goal is to identify chromosomal regions that harbor genes that affect the components of bone fragility and predisposition to fracture. Identification of these genes may: 1) lead to molecular tests that predict the risk of osteoporosis, thereby allowing the early institution of preventive measures; 2) provide insight into the basic skeletal biology that underlies bone fragility and the predisposition to fracture; and 3) identify molecular targets for the development of therapeutic agents aimed at increasing bone strength.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG018397-03
Application #
6509923
Study Section
Special Emphasis Panel (ZAG1-BJB-9 (M3))
Program Officer
Carrington, Jill L
Project Start
2000-09-30
Project End
2005-06-30
Budget Start
2002-08-01
Budget End
2003-06-30
Support Year
3
Fiscal Year
2002
Total Cost
$1,936,398
Indirect Cost

  Institution

Name
Indiana University-Purdue University at Indianapolis
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202

  Publications

Robinson-Cohen, Cassianne; Bartz, Traci M; Lai, Dongbing et al. (2018) Genetic Variants Associated with Circulating Fibroblast Growth Factor 23. J Am Soc Nephrol 29:2583-2592
Zeng, Y; Zhang, L; Zhu, W et al. (2017) Network based subcellular proteomics in monocyte membrane revealed novel candidate genes involved in osteoporosis. Osteoporos Int 28:3033-3042
Koller, Daniel L; Imel, Erik A; Lai, Dongbing et al. (2016) Genome-wide association study of serum iron phenotypes in premenopausal women of European descent. Blood Cells Mol Dis 57:50-3
Pei, Yu-Fang; Tian, Qing; Zhang, Lei et al. (2016) Exploring the Major Sources and Extent of Heterogeneity in a Genome-Wide Association Meta-Analysis. Ann Hum Genet 80:113-22
Pei, Yu-Fang; Hu, Wen-Zhu; Hai, Rong et al. (2016) Genome-wide association meta-analyses identified 1q43 and 2q32.2 for hip Ward's triangle areal bone mineral density. Bone 91:1-10
Niu, Tianhua; Liu, Ning; Yu, Xun et al. (2016) Identification of IDUA and WNT16 Phosphorylation-Related Non-Synonymous Polymorphisms for Bone Mineral Density in Meta-Analyses of Genome-Wide Association Studies. J Bone Miner Res 31:358-68
Liu, Yao-Zhong; Zhou, Yu; Zhang, Lei et al. (2015) Attenuated monocyte apoptosis, a new mechanism for osteoporosis suggested by a transcriptome-wide expression study of monocytes. PLoS One 10:e0116792
Pei, Yu-Fang; Zhang, Lei; Liu, Yongjun et al. (2014) Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity. Hum Mol Genet 23:820-30
Zhang, Lei; Choi, Hyung Jin; Estrada, Karol et al. (2014) Multistage genome-wide association meta-analyses identified two new loci for bone mineral density. Hum Mol Genet 23:1923-33
Alam, Imranul; Padgett, Leah R; Ichikawa, Shoji et al. (2014) SIBLING family genes and bone mineral density: association and allele-specific expression in humans. Bone 64:166-72

Showing the most recent 10 out of 86 publications