(from the application): The Micro array Core of the Program Project (Core C) will: 1) provide training and consultation in the methodologies, necessary for the use of micro arrayed cDNAs, (this includes discussion of experimental design, isolation of RNA generation of dye-labeled cDNAs, development of standard RNA reference pools; and hybridization of chips with labeled cDNA pools); 2) carry out the labeling and hybridization for program project members; 3) provide chips and reagents necessary for labeling cDNA probe populations at reduced cost; and 4) scan the hybridized slides and provide the program project members with the processed quantitative data derived from the micro array. The Micro array Core provides the capability to conduct a broad screen of gene expression changes (e.g., old versus young) that is far more efficient than current technologies.
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| Iakova, Polina; Timchenko, Lubov; Timchenko, Nikolai A (2011) Intracellular signaling and hepatocellular carcinoma. Semin Cancer Biol 21:28-34 |
| Singh, Pallavi; Goode, Triona; Dean, Adam et al. (2011) Elevated interferon gamma signaling contributes to impaired regeneration in the aged liver. J Gerontol A Biol Sci Med Sci 66:944-56 |
| Hornsby, Peter J (2011) Cellular aging and cancer. Crit Rev Oncol Hematol 79:189-95 |
| Jin, Jingling; Wang, Guo-Li; Iakova, Polina et al. (2010) Epigenetic changes play critical role in age-associated dysfunctions of the liver. Aging Cell 9:895-910 |
| Wang, Guo-Li; Shi, Xiurong; Haefliger, Simon et al. (2010) Elimination of C/EBPalpha through the ubiquitin-proteasome system promotes the development of liver cancer in mice. J Clin Invest 120:2549-62 |
| Lin, Qiushi; Chen, Dahu; Timchenko, Nikolai A et al. (2010) SKI promotes Smad3 linker phosphorylations associated with the tumor-promoting trait of TGFbeta. Cell Cycle 9:1684-9 |
| Cardoso, Cibele C; Bornstein, Stefan R; Hornsby, Peter J (2010) Optimizing orthotopic cell transplantation in the mouse adrenal gland. Cell Transplant 19:565-72 |
| Willis-Martinez, Danielle; Richards, Hunter W; Timchenko, Nikolai A et al. (2010) Role of HDAC1 in senescence, aging, and cancer. Exp Gerontol 45:279-85 |
| Orellana, Daniel; Liu, Xiaoying; Wang, Gou-Li et al. (2010) Calmodulin controls liver proliferation via interactions with C/EBPbeta-LAP and C/EBPbeta-LIP. J Biol Chem 285:23444-56 |
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