The primary goal of this Program project is to use the rhesus macaque model to explore features of immune aging, in order to subsequently devise methods and vaccines to enhance immunity in elderly humans. The four proposed Projects focus on synergistically evaluating the age-related changes of immunity in vivo. Therefore, the monkey cohorts to be studied have been unified in a single plan so that the scientific goals of each of these projects is met using the same animals. This approach not only makes the most efficient use of the animal resource, but also allows full cross-correlation of the various immunologic features of senescence in each animal. The Animal Core, functioning within the Oregon National Primate Center, will be responsible for managing all of the rhesus macaque studies in this project, including: 1) their selection for study, 2) their housing and general husbandry, 3) their clinical management and manipulation, 4) specimen collection and processing, and 5) necropsy studies. The Core will interact closely with project leaders and project laboratory personnel to facilitate the accomplishment of the programmatic goals.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG023664-05
Application #
7675413
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2008-06-01
Budget End
2009-05-31
Support Year
5
Fiscal Year
2008
Total Cost
$443,547
Indirect Cost
Name
Oregon Health and Science University
Department
Type
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Hammarlund, Erika; Thomas, Archana; Amanna, Ian J et al. (2017) Plasma cell survival in the absence of B cell memory. Nat Commun 8:1781
Ouwendijk, Werner J D; van Veen, Suzanne; Mahalingam, Ravi et al. (2017) Simian varicella virus inhibits the interferon gamma signalling pathway. J Gen Virol :
Henderson, Heather H; Timberlake, Kensey B; Austin, Zoe A et al. (2016) Occupancy of RNA Polymerase II Phosphorylated on Serine 5 (RNAP S5P) and RNAP S2P on Varicella-Zoster Virus Genes 9, 51, and 66 Is Independent of Transcript Abundance and Polymerase Location within the Gene. J Virol 90:1231-43
Ouwendijk, Werner J D; Getu, Sarah; Mahalingam, Ravi et al. (2016) Characterization of the immune response in ganglia after primary simian varicella virus infection. J Neurovirol 22:376-88
Okoye, Afam A; Rohankhedkar, Mukta; Konfe, Audrie L et al. (2015) Effect of IL-7 Therapy on Naive and Memory T Cell Homeostasis in Aged Rhesus Macaques. J Immunol 195:4292-305
Verweij, Marieke C; Wellish, Mary; Whitmer, Travis et al. (2015) Varicella Viruses Inhibit Interferon-Stimulated JAK-STAT Signaling through Multiple Mechanisms. PLoS Pathog 11:e1004901
High, Kevin P; Akbar, Arne N; Nikolich-Zugich, Janko (2012) Translational research in immune senescence: assessing the relevance of current models. Semin Immunol 24:373-82
Cicin-Sain, Luka; Brien, James D; Uhrlaub, Jennifer L et al. (2012) Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging. PLoS Pathog 8:e1002849
Cicin-Sain, Luka; Sylwester, Andrew W; Hagen, Shoko I et al. (2011) Cytomegalovirus-specific T cell immunity is maintained in immunosenescent rhesus macaques. J Immunol 187:1722-32
Lang, Anna; Nikolich-Zugich, Janko (2011) Functional CD8 T cell memory responding to persistent latent infection is maintained for life. J Immunol 187:3759-68

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