To determine the impact of an experimental intervention on aging, it is essential that an investigator have knowledge of how the intervention alters the pathological lesions that occur with age. Age-related pathology increases exponentially with advancing age and is largely responsible for age-related morbidity as well as mortality. Pathological information also provides investigators with insight into the potential biological/molecular mechanism(s) of the intervention. Furthermore, the pathological assessment of old animals that are included in basic studies of biological aging processes is necessary to help investigators determine whether the changes in physiological/biochemical parameters measured are associated with or are independent of underlying pathological conditions. Thus it is essential to obtain accurate and thorough pathological assessments of aging animals. The Pathology Core will provide investigators in the three Projects with detailed end-of-life pathological analyses of the lesions that occur with age in colonies of tissue-specific (liver, skeletal muscle and white adipose tissue [WAT]) GHRKO mice . The Pathology Core will also provide investigators in the four Projects with cross-sectional pathological analyses of the specific tissues obtained from Ames dwarf, GHRKO and tissue-specific GHRKO mice.
The Specific Aims of the Pathology Core are as follows:
Aim 1 : To conduct comprehensive pathological analyses of the genetically manipulated mice and their wild- type littermates that die spontaneously or are in the moribund category in the aging colonies.
Aim 2 : To conduct cross-sectional histopathological analyses of tissues obtained from genetically manipulated mice and their littermates. These data will allow investigators to evaluate the effect of the genetic manipulations on the histological changes in specific tissues at specific age.
| Nelson, Caroline N; List, Edward O; Ieremia, Makerita et al. (2018) Growth hormone activated STAT5 is required for induction of beige fat in vivo. Growth Horm IGF Res 42-43:40-51 |
| Duran-Ortiz, Silvana; Noboa, Vanessa; Kopchick, John J (2018) Disruption of the GH receptor gene in adult mice and in insulin sensitive tissues. Growth Horm IGF Res 38:3-7 |
| Fang, Yimin; Hill, Cristal M; Darcy, Justin et al. (2018) Effects of rapamycin on growth hormone receptor knockout mice. Proc Natl Acad Sci U S A 115:E1495-E1503 |
| Householder, Lara A; Comisford, Ross; Duran-Ortiz, Silvana et al. (2018) Increased fibrosis: A novel means by which GH influences white adipose tissue function. Growth Horm IGF Res 39:45-53 |
| Schneider, Augusto; Matkovich, Scot J; Saccon, Tatiana et al. (2017) Ovarian transcriptome associated with reproductive senescence in the long-living Ames dwarf mice. Mol Cell Endocrinol 439:328-336 |
| Dominick, Graham; Bowman, Jacqueline; Li, Xinna et al. (2017) mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice. Aging Cell 16:52-60 |
| Bartke, Andrzej; Darcy, Justin (2017) GH and ageing: Pitfalls and new insights. Best Pract Res Clin Endocrinol Metab 31:113-125 |
| Bennis, Mohammed T; Schneider, Augusto; Victoria, Berta et al. (2017) The role of transplanted visceral fat from the long-lived growth hormone receptor knockout mice on insulin signaling. Geroscience 39:51-59 |
| Saccon, Tatiana D; Moreira, Fabiana; Cruz, Luis A et al. (2017) Ovarian aging and the activation of the primordial follicle reserve in the long-lived Ames dwarf and the short-lived bGH transgenic mice. Mol Cell Endocrinol 455:23-32 |
| Hascup, Kevin N; Lynn, Mary K; Fitzgerald, Patrick J et al. (2017) Enhanced Cognition and Hypoglutamatergic Signaling in a Growth Hormone Receptor Knockout Mouse Model of Successful Aging. J Gerontol A Biol Sci Med Sci 72:329-337 |
Showing the most recent 10 out of 144 publications
