The Scientific Core provides an organizational structure for scientific efforts common to all projects within the program to achieve the overall goals and vision of the Program Project as an integrated investigation in diseases caused by VZV in the elderly. The Core Leader, Dr. Maria Nagel, meets with the Clinical Coordinator daily to prioritize scientific efforts on all human and monkey specimens and to plan strategies and evaluate data. The Scientific Core provides support for the Clinical Coordinator, who will acquire, bank, process and computerize all tissue from humans in Projects 1 and 2 and from monkeys in Project 3, as well as ensure compliance with regulatory bodies including the Colorado Multiple Institutional Review Board. The Scientific Core also provides support in all 3 projects for: a bioinformatics expert to assist with RNA sequencing, data analysis and interpretation, and training of laboratory personnel in these analyses; a statistical consultant; an editorial consultant and publication costs; common-use supplies and equipment for tissue culture, PCR and gene expression profiling/RNA sequencing; and continuing service contracts, maintenance and repair of heavy equipment and computer costs.
| Como, Christina N; Pearce, Catherine M; Cohrs, Randall J et al. (2018) Interleukin-6 and type 1 interferons inhibit varicella zoster virus replication in human neurons. Virology 522:13-18 |
| Mahalingam, Ravi; Kaufer, Benedikt B; Ouwendijk, Werner J D et al. (2018) Attenuation of Simian Varicella Virus Infection by Enhanced Green Fluorescent Protein in Rhesus Macaques. J Virol 92: |
| Cohrs, Randall J; Badani, Hussain; Baird, Nicholas L et al. (2017) Induction of varicella zoster virus DNA replication in dissociated human trigeminal ganglia. J Neurovirol 23:152-157 |
| Cohrs, Randall J; Lee, Katherine S; Beach, Addilynn et al. (2017) Targeted Genome Sequencing Reveals Varicella-Zoster Virus Open Reading Frame 12 Deletion. J Virol 91: |
| Nagel, Maria A; Jones, Dallas; Wyborny, Ann (2017) Varicella zoster virus vasculopathy: The expanding clinical spectrum and pathogenesis. J Neuroimmunol 308:112-117 |
| Ouwendijk, Werner J D; van Veen, Suzanne; Mahalingam, Ravi et al. (2017) Simian varicella virus inhibits the interferon gamma signalling pathway. J Gen Virol : |
| Cohrs, Randall J; Badani, Hussain; Bos, Nathan et al. (2016) Alphaherpesvirus DNA replication in dissociated human trigeminal ganglia. J Neurovirol 22:688-694 |
| Nagel, Maria A; Gilden, Don (2016) Developments in Varicella Zoster Virus Vasculopathy. Curr Neurol Neurosci Rep 16:12 |
| Yawn, Barbara P; Wollan, Peter C; Nagel, Maria A et al. (2016) Risk of Stroke and Myocardial Infarction After Herpes Zoster in Older Adults in a US Community Population. Mayo Clin Proc 91:33-44 |
| Gilden, Don; Nagel, Maria A (2016) Varicella zoster virus and giant cell arteritis. Curr Opin Infect Dis 29:275-9 |
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