Abstract

The Animal and Biostatistics Core will work directly with Project Leaders to design, plan, monitor and interpret all animal experiments, as well as, provide specific mouse models and standardized experimental protocols in support of the overall program hypothesis that the understanding of the mechanisms of dietary restriction and reduced growth hormone/insulin growth factor (GH/IGF) signaling-dependent cellular protection can be applied to the prevention and treatment of age-related diseases. Mouse breeding colonies of unique genetic and molecular phenotypes which target specific tissue or cellular GH/IGF pathways are the source of offspring to be characterized for longevity, stress resistance, spontaneous cancer development and protection from oxidative damage and established chemotherapy drugs. The core provides an integrative framework for assessment of common outcomes across the individual projects needs.

Public Health Relevance

The Animal and Biostatistics Core will apply the expertise of its leaders to improve the design, execution, interpretation, and publication of all animal studies proposed in this program project. The Animal and Biostatistics Core will monitor all animal experiments using specific mouse models and standardized experimental protocols to provide an integrative framework for assessment of common outcomes across the individual projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG034906-02
Application #
8374429
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5)
Project Start
Project End
Budget Start
2012-03-01
Budget End
2013-02-28
Support Year
2
Fiscal Year
2012
Total Cost
$456,941
Indirect Cost
$174,879

  Institution

Name
University of Southern California
Department
Type
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Mao, Kai; Quipildor, Gabriela Farias; Tabrizian, Tahmineh et al. (2018) Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice. Nat Commun 9:2394
Kim, Su-Jeong; Mehta, Hemal H; Wan, Junxiang et al. (2018) Mitochondrial peptides modulate mitochondrial function during cellular senescence. Aging (Albany NY) 10:1239-1256
Xiao, Jialin; Cohen, Pinchas; Stern, Mariana Carla et al. (2018) Mitochondrial biology and prostate cancer ethnic disparity. Carcinogenesis 39:1311-1319
Nencioni, Alessio; Caffa, Irene; Cortellino, Salvatore et al. (2018) Fasting and cancer: molecular mechanisms and clinical application. Nat Rev Cancer 18:707-719
Qin, Qing; Delrio, Silvia; Wan, Junxiang et al. (2018) Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction. Int J Cardiol 254:23-27
Guidi, Novella; Longo, Valter D (2018) Periodic fasting starves cisplatin-resistant cancers to death. EMBO J 37:
Buono, Roberta; Longo, Valter D (2018) Starvation, Stress Resistance, and Cancer. Trends Endocrinol Metab 29:271-280
Qin, Qing; Mehta, Hemal; Yen, Kelvin et al. (2018) Chronic treatment with the mitochondrial peptide humanin prevents age-related myocardial fibrosis in mice. Am J Physiol Heart Circ Physiol 315:H1127-H1136
Lee, Amy S; Brandhorst, Sebastian; Rangel, Daisy F et al. (2017) Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice. Sci Rep 7:40919
Ben-Avraham, Danny; Govindaraju, Diddahally R; Budagov, Temuri et al. (2017) The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature. Sci Adv 3:e1602025

Showing the most recent 10 out of 81 publications