The Administrative Core (Core A) will continue to provide the mechanism and structure to plan, evaluate, and manage the four Projects and two other Cores in this Program Project (PPG). The goals of Core A are to provide scientific, programmatic, and fiscal leadership and facilitate communication between all researchers to ensure that the Projects fulfill the goals set forth in the proposal and meet the administrative and financial requirements of the NIH, the University of Rochester, and the two other institutions involved, Harvard Medical School in Boston, and the Albert Einstein College of Medicine in New York. Core A will facilitate monthly meetings by videoconference and annual face-to-face meetings. The Core will also be responsible for the communication between the PPG and the NIH. Further, the Core will ensure that the results of each Project are disseminated in a timely manner for the benefit of the scientific community. To this end, Core A will facilitate the submission of joint publications and, in collaboration with Core C, will maintain a database for all biological specimens and data generated by the Projects and Cores. Finally, Core A will organize the biennial reviews by the external Scientific Advisory Board.
| Seluanov, Andrei; Gladyshev, Vadim N; Vijg, Jan et al. (2018) Mechanisms of cancer resistance in long-lived mammals. Nat Rev Cancer 18:433-441 |
| Meer, Margarita V; Podolskiy, Dmitriy I; Tyshkovskiy, Alexander et al. (2018) A whole lifespan mouse multi-tissue DNA methylation clock. Elife 7: |
| Tian, Xiao; Doerig, Katherine; Park, Rosa et al. (2018) Evolution of telomere maintenance and tumour suppressor mechanisms across mammals. Philos Trans R Soc Lond B Biol Sci 373: |
| Zhou, Xuming; Sun, Di; Guang, Xuanmin et al. (2018) Molecular Footprints of Aquatic Adaptation Including Bone Mass Changes in Cetaceans. Genome Biol Evol 10:967-975 |
| Piscitello, D; Varshney, D; Lilla, S et al. (2018) AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11. Oncogene 37:427-438 |
| Swovick, Kyle; Welle, Kevin A; Hryhorenko, Jennifer R et al. (2018) Cross-species Comparison of Proteome Turnover Kinetics. Mol Cell Proteomics 17:580-591 |
| Sziráki, András; Tyshkovskiy, Alexander; Gladyshev, Vadim N (2018) Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction. Aging Cell 17:e12738 |
| Hébert, Jean M; Vijg, Jan (2018) Cell Replacement to Reverse Brain Aging: Challenges, Pitfalls, and Opportunities. Trends Neurosci 41:267-279 |
| Tian, Xiao; Seluanov, Andrei; Gorbunova, Vera (2017) Molecular Mechanisms Determining Lifespan in Short- and Long-Lived Species. Trends Endocrinol Metab 28:722-734 |
| Ma, Siming; Gladyshev, Vadim N (2017) Molecular signatures of longevity: Insights from cross-species comparative studies. Semin Cell Dev Biol 70:190-203 |
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