Abstract

This Program Project deals with humoral and cellular studies of the IgA system in health and disease. The component projects represent an array of interrelated studies of the immune responses of the secretory and systemic IgA systems to environmental substances including food, bacterial and viral antigens in normal individuals and inpatients with abnormalities of the immune system. In normal adults daily production of IgA exceeds that of other immunoglobulin isotypes. Yet, from the functional point of view, the role of both, secretory and serum IgA in immune protection, and in regulation of immune responses is completely misunderstood. The proposed studies include: Project I: Common Mucosal System in Humans Project II: Immunopathogenesis of IgA Nephropathy Project III: Regulation of IgA Autoantibodies Project IV: B Cell Ontogeny and Fc alpha Receptors These projects are interrelated at both conceptional and technical levels because of the common interest of participating investigators in IgA physiology and immunopathology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI018745-09
Application #
3091531
Study Section
Allergy & Clinical Immunology-1 (AITC)
Project Start
1982-09-01
Project End
1992-03-31
Budget Start
1990-04-01
Budget End
1991-03-31
Support Year
9
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Type
Schools of Dentistry
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Renegar, Kathryn B; Menge, Alan; Mestecky, Jiri (2006) Influenza virus infection of the murine uterus: a new model for antiviral immunity in the female reproductive tract. Viral Immunol 19:613-22
Edwards, R P; Pitts, A; Crowley-Nowick, P et al. (1996) Immunoglobulin-containing plasma cells recruited to cervical neoplasia. Obstet Gynecol 87:520-6
Hunley, T E; Julian, B A; Phillips 3rd, J A et al. (1996) Angiotensin converting enzyme gene polymorphism: potential silencer motif and impact on progression in IgA nephropathy. Kidney Int 49:571-7
Crowley-Nowick, P A; Campbell, E; Schrohenloher, R E et al. (1996) Polyethylene glycol precipitates of serum contain a large proportion of uncomplexed immunoglobulins and C3. Immunol Invest 25:91-101
Edwards, R P; Kuykendall, K; Crowley-Nowick, P et al. (1995) T lymphocytes infiltrating advanced grades of cervical neoplasia. CD8-positive cells are recruited to invasion. Cancer 76:1411-5
Lue, C; Van den Wall Blake, A W; Prince, S J et al. (1995) Intraperitoneal administration of tetanus toxoid elicits a specific response of antibody-secreting cells in the peritoneal cavity. Adv Exp Med Biol 371A:103-6
Moldoveanu, Z; Russell, M W; Wu, H Y et al. (1995) Compartmentalization within the common mucosal immune system. Adv Exp Med Biol 371A:97-101
Moldoveanu, Z; Clements, M L; Prince, S J et al. (1995) Human immune responses to influenza virus vaccines administered by systemic or mucosal routes. Vaccine 13:1006-12
Lue, C; van den Wall Bake, A W; Prince, S J et al. (1994) Intraperitoneal immunization of human subjects with tetanus toxoid induces specific antibody-secreting cells in the peritoneal cavity and in the circulation, but fails to elicit a secretory IgA response. Clin Exp Immunol 96:356-63
Go, M F; Schrohenloher, R E; Tomana, M (1994) Deficient galactosylation of serum IgG in inflammatory bowel disease: correlation with disease activity. J Clin Gastroenterol 18:86-7

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